Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5082567 | 0.88 | IGF1R (0.44) | IGF1RTNK2HPGDJAK2ADORA2A | |
| SCHEMBL5083787 | 0.86 | TNK2 (0.42) | IGF1RTNK2HPGDJAK2ADORA2A | |
| SCHEMBL5086253 | 0.85 | TNK2 (0.50) | IGF1RTNK2ABL1 | |
| SCHEMBL4073244 | 0.81 | IGF1R (0.51) | IGF1RTNK2 | |
| SCHEMBL401177 | 0.79 | TNK2 (0.68) | IGF1RTNK2 | |
| SCHEMBL3040790 | 0.78 | IGF1R (0.51) | IGF1RTNK2HPGDJAK2ADORA2A | |
| SCHEMBL5080636 | 0.77 | IGF1R (0.48) | IGF1RTNK2JAK2ADORA2AADORA1 | |
| SCHEMBL3898556 | 0.76 | TNK2 (0.52) | IGF1RTNK2 | |
| SCHEMBL401241 | 0.76 | IGF1R (0.44) | IGF1RTNK2 | |
| SCHEMBL398892 | 0.76 | IGF1R (0.45) | IGF1RTNK2ADORA2AADORA1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |