Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 11/20 | 0.50 |
| ▸ | IGF1R | P08069 | 6/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5084882 | 0.91 | IGF1R (0.48) | TNK2IGF1R | |
| SCHEMBL5083787 | 0.85 | TNK2 (0.42) | TNK2IGF1RABL1 | |
| SCHEMBL5086076 | 0.85 | IGF1R (0.44) | TNK2IGF1RABL1 | |
| SCHEMBL5081320 | 0.83 | TNK2 (0.44) | TNK2IGF1R | |
| SCHEMBL5082567 | 0.83 | IGF1R (0.44) | TNK2IGF1R | |
| SCHEMBL5086140 | 0.81 | TNK2 (0.45) | TNK2IGF1R | |
| SCHEMBL4073244 | 0.80 | IGF1R (0.51) | TNK2IGF1R | |
| SCHEMBL397651 | 0.79 | TNK2 (0.78) | TNK2IGF1R | |
| SCHEMBL5081252 | 0.79 | TNK2 (0.42) | TNK2IGF1RABL1KLKB1 | |
| SCHEMBL396775 | 0.77 | TNK2 (0.65) | TNK2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | claimed |