Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5082824 | 0.88 | SLC6A2 (0.53) | — | |
| SCHEMBL11447883 | 0.74 | LTA4H (0.50) | KDM4E | |
| SCHEMBL4668992 | 0.74 | SCN1A (0.58) | CHRNA7KMT2AKDM4E | |
| SCHEMBL2841877 | 0.74 | LTA4H (0.55) | POLB | |
| SCHEMBL2841875 | 0.74 | LTA4H (0.55) | POLB | |
| SCHEMBL11448239 | 0.72 | LTA4H (0.46) | POLB | |
| SCHEMBL678328 | 0.72 | SLC6A3 (0.47) | POLBCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL11629768 | 0.72 | POLB (0.56) | POLBCACNA2D1CACNA1BCACNB1KMT2A | |
| SCHEMBL14160114 | 0.71 | SCN1A (0.55) | CHRNA7KMT2AKDM4E | |
| SCHEMBL14160236 | 0.71 | SCN1A (0.55) | CHRNA7KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008133884-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-11-06 | — | — | WO | disclosed |