Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.34 |
| ▸ | IGF1R | P08069 | 15/20 | 0.34 |
| ▸ | PIM1 | P11309 | 3/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.33 |
| ▸ | INSR | P06213 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5085504 | 0.88 | IGF1R (0.34) | IGF1R | |
| SCHEMBL5082570 | 0.83 | TNK2 (0.39) | IGF1RINSR | |
| SCHEMBL5080364 | 0.81 | IGF1R (0.36) | IGF1RINSR | |
| SCHEMBL399465 | 0.76 | IGF1R (0.57) | IGF1R | |
| SCHEMBL399321 | 0.71 | EGFR (0.59) | IGF1RINSR | |
| SCHEMBL5083797 | 0.69 | IGF1R (0.38) | IGF1RINSR | |
| SCHEMBL5087010 | 0.69 | IGF1R (0.39) | IGF1R | |
| SCHEMBL5080636 | 0.68 | IGF1R (0.48) | IGF1R | |
| SCHEMBL4356352 | 0.68 | GSK3B (0.41) | IGF1RINSR | |
| SCHEMBL5085414 | 0.67 | TNK2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | claimed |