Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 2/20 | 0.33 |
| ▸ | VCP | P55072 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5080636 | 0.88 | IGF1R (0.48) | IGF1RABL1TNK2ATRGSK3B | |
| SCHEMBL5081252 | 0.85 | TNK2 (0.42) | IGF1RABL1TNK2PIK3CDPIK3R2 | |
| SCHEMBL5085373 | 0.85 | IGF1R (0.43) | IGF1RABL1TNK2PIK3CGMEN1 | |
| SCHEMBL5082589 | 0.82 | IGF1R (0.41) | IGF1RABL1TNK2KDM4EMAPT | |
| SCHEMBL5083787 | 0.79 | TNK2 (0.42) | IGF1RABL1TNK2GSK3BPIK3CD | |
| SCHEMBL400351 | 0.79 | IGF1R (0.59) | IGF1RTNK2PIK3CG | |
| SCHEMBL5083298 | 0.78 | IGF1R (0.40) | IGF1RTNK2ATRMAPTMEN1 | |
| SCHEMBL5080364 | 0.73 | IGF1R (0.36) | IGF1RTNK2CCNA2CDK2CDK5 | |
| SCHEMBL5083797 | 0.73 | IGF1R (0.38) | IGF1RTNK2 | |
| SCHEMBL5084882 | 0.72 | IGF1R (0.48) | IGF1RTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | claimed |
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |