Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 8/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5083455 | 0.88 | DHFR (0.34) | IGF1R | |
| SCHEMBL5085520 | 0.84 | IGF1R (0.40) | IGF1R | |
| SCHEMBL400050 | 0.78 | IGF1R (0.54) | IGF1R | |
| SCHEMBL5082570 | 0.75 | TNK2 (0.39) | IGF1R | |
| SCHEMBL5083298 | 0.72 | IGF1R (0.40) | IGF1RMEN1KMT2A | |
| SCHEMBL4356352 | 0.67 | GSK3B (0.41) | IGF1RABL1 | |
| SCHEMBL5083797 | 0.66 | IGF1R (0.38) | IGF1R | |
| SCHEMBL402030 | 0.66 | IGF1R (0.68) | IGF1R | |
| SCHEMBL399465 | 0.65 | IGF1R (0.57) | IGF1R | |
| SCHEMBL5085414 | 0.64 | TNK2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979002-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007075554-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |