SCHEMBL5083723

SCHEMBL5083723

CC1=C(C)C(C)C([Si](C)(C)c2cc(C)cc(C(C)(C)C)c2OCc2ccccc2)=C1C

nearest known ligand 0.34

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FEN1 P39748 1/20 0.34
ALOX5AP P20292 1/20 0.33
RXRA P19793 1/20 0.33
RXRB P28702 1/20 0.33
RXRG P48443 1/20 0.33
LMNA P02545 1/20 0.32
GAA P10253 1/20 0.32
MRGPRX4 Q96LA9 1/20 0.32
TSHR P16473 1/20 0.31
HTT P42858 2/20 0.31
NPC1 O15118 1/20 0.31
BRD4 O60885 1/20 0.30
POLB P06746 1/20 0.30
STAT3 P40763 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5085909 0.83 CYP3A4 (0.32)
SCHEMBL4761592 0.81 CYP3A4 (0.31)
SCHEMBL1902667 0.81 ALDH1A1 (0.33) TSHRPOLBSMN1; SMN2
SCHEMBL5090134 0.79
SCHEMBL5083880 0.78
SCHEMBL27738669 0.76 MAPT (0.44) FEN1ALOX5APRXRARXRBRXRG
SCHEMBL12842326 0.74 FEN1 (0.41) FEN1ALOX5APRXRARXRBRXRG
SCHEMBL7984096 0.72 PTGS2 (0.32) TSHR
SCHEMBL5086940 0.71 ACHE (0.31)
SCHEMBL5090011 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1498178-B1 Transition metal complex and process for producing the same SUMITOMO CHEMICAL CO (JP) 2008-06-11 EP disclosed
EP-1498178-A2 Transition metal complex, process for producing the same, olefin polymerization catalyst containing the transition metal complex and process for producing olefin polymers Sumitomo Chemical Company, Limited (JP) 2005-01-19 EP disclosed
EP-0842939-B1 OLEFIN POLYMERIZATION CATALYST CONTAINING A TRANSITION METAL COMPLEX AND PROCESS FOR PRODUCING OLEFIN POLYMERS SUMITOMO CHEMICAL CO (JP) 2004-10-06 EP disclosed
US-6329478-B1 SOLUBILITY IN SATURATED HYDROCARBON SOLVENTS SUMITMO CHEMICAL COMPANY, LIMITED 2001-12-11 US disclosed
EP-0842939-A1 TRANSITION METAL COMPLEX, PROCESS FOR THE PREPARATION THEREOF, POLYMERIZATION CATALYST FOR OLEFINS CONTAINING THE COMPLEX, AND PROCESS FOR PRODUCING OLEFIN POLYMERS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-05-20 EP disclosed