Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 4/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30633059 | 1.00 | HSP90AB1 (0.46) | HSP90AB1DPP4RORCMTNR1AMTNR1B | |
| SCHEMBL725284 | 0.87 | DPP4 (0.41) | HSP90AB1DPP4RORCMTNR1AMTNR1B | |
| SCHEMBL30167907 | 0.87 | DPP4 (0.41) | HSP90AB1DPP4RORCMTNR1AMTNR1B | |
| SCHEMBL22527805 | 0.85 | RORC (0.41) | HSP90AB1DPP4RORCMTNR1AMTNR1B | |
| SCHEMBL29737923 | 0.85 | RORC (0.41) | HSP90AB1DPP4RORCMTNR1AMTNR1B | |
| SCHEMBL2399645 | 0.83 | MTNR1A (0.49) | HSP90AB1RORCMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL328578 | 0.83 | ALDH1A1 (0.46) | HSP90AB1DPP4RORCMTNR1AMTNR1B | |
| SCHEMBL7881526 | 0.82 | PDGFRB (0.48) | HSP90AB1DPP4RORCMTNR1AMTNR1B | |
| SCHEMBL23832263 | 0.81 | MAPT (0.40) | HSP90AB1RORCMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL30154484 | 0.81 | MAPT (0.40) | HSP90AB1RORCMTNR1AMTNR1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115246762-A | Preparation method of 2,4,5-trifluorophenylacetic acid | 上海朴颐化学科技有限公司 | 2022-10-28 | — | — | CN | claimed |
| CN-116947638-A | Method for preparing sitagliptin intermediate by one-pot method | 淄博飞源化工有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-115246762-A | Preparation method of 2,4,5-trifluorophenylacetic acid | 上海朴颐化学科技有限公司 | 2022-10-28 | — | — | CN | disclosed |
| CN-115246762-A | Preparation method of 2,4,5-trifluorophenylacetic acid | 上海朴颐化学科技有限公司 | 2022-10-28 | — | — | CN | disclosed |
| US-10913747-B2 | Efficient process for the preparation of sitagliptin through a very effective preparation of the intermediate 2,4,5-trifluorophenylacetic acid | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2021-02-09 | — | — | US | disclosed |
| US-20200157109-A1 | EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN THROUGH A VERY EFFECTIVE PREPARATION OF THE INTERMEDIATE 2,4,5-TRIFLUOROPHENYLACETIC ACID | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2020-05-21 | — | — | US | disclosed |
| EP-3424927-B1 | EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN THROUGH A VERY EFFECTIVE PREPARATION OF THE INTERMEDIATE 2,4,5-TRIFLUOROPHENYLACETIC ACID | FIS FABBRICA ITALIANA SINTETICI SPA (IT) | 2019-04-17 | — | — | EP | disclosed |
| WO-2019007578-A1 | EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN THROUGH A VERY EFFECTIVE PREPARATION OF THE INTERMEDIATE 2,4,5-TRIFLUOROPHENYLACETIC ACID | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2019-01-10 | — | — | WO | disclosed |
| EP-3424927-A1 | EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN THROUGH A VERY EFFECTIVE PREPARATION OF THE INTERMEDIATE 2,4,5-TRIFLUOROPHENYLACETIC ACID | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2019-01-09 | — | — | EP | disclosed |
| WO-2008078350-A2 | PROCESS FOR THE PREPARATION OF FLUOROPHENYLACETIC ACIDS AND DERIVATIVES THEREOF | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157109-A1 | EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN THROUGH A VERY EFFECTIVE PREPARATION OF THE INTERMEDIATE 2,4,5-TRIFLUOROPHENYLACETIC ACID | DPP4, DPP9, DPP7 | HSP90AB1 3465/4885DPP4 1/4885RORC 4521/4885 |
| US-10913747-B2 | Efficient process for the preparation of sitagliptin through a very effective preparation of the intermediate 2,4,5-trifluorophenylacetic acid | DPP4, DPP9, DPP7 | HSP90AB1 3465/4885DPP4 1/4885RORC 4521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.