Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 2/20 | 1.00 |
| ▸ | NFKB2 | Q00653 | 2/20 | 1.00 |
| ▸ | RELA | Q04206 | 2/20 | 1.00 |
| ▸ | SLC5A1 | P13866 | 8/20 | 0.91 |
| ▸ | SLC5A2 | P31639 | 7/20 | 0.91 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | TTR | P02766 | 1/20 | 0.66 |
| ▸ | ESR1 | P03372 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL457127 | 0.95 | SLC5A1 (1.00) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| Asebogenin SCHEMBL4740064 | 0.94 | NFKB1 (0.88) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL2282039 | 0.91 | NFKB1 (0.83) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL15457885 | 0.91 | NFKB1 (0.83) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL1682159 | 0.91 | NFKB1 (0.83) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL4742840 | 0.89 | NFKB1 (0.80) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL15457887 | 0.88 | NFKB1 (0.78) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL8115827 | 0.87 | NFKB1 (0.77) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL1938352 | 0.87 | SLC5A1 (0.84) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL11293573 | 0.86 | NFKB1 (0.75) | NFKB1NFKB2RELASLC5A1SLC5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260048027-A1 | METHYLATED PHLORETIN ANALOGS AS INHIBITORS OF SGLT2 | NESTLE SA (CH) | 2026-02-19 | — | — | US | claimed |
| EP-4655410-A2 | O-METHYLATION OF PHENOLIC SUBSTANCES VIA FUNGAL O-METHYLTRANSFERASE | Symrise AG (DE) | 2025-12-03 | — | — | EP | claimed |
| EP-4572749-A1 | METHYLATED PHLORETIN ANALOGS AS INHIBITORS OF SGLT2 | Société des Produits Nestlé S.A. (CH) | 2025-06-25 | — | — | EP | claimed |
| WO-2024156359-A1 | O-METHYLATION OF PHENOLIC SUBSTANCES VIA FUNGAL O-METHYLTRANSFERASE | SYMRISE AG (DE) | 2024-08-02 | — | — | WO | claimed |
| WO-2024156879-A2 | O-METHYLATION OF PHENOLIC SUBSTANCES VIA FUNGAL O-METHYLTRANSFERASE | SYMRISE AG (DE) | 2024-08-02 | — | — | WO | claimed |
| WO-2024038011-A1 | METHYLATED PHLORETIN ANALOGS AS INHIBITORS OF SGLT2 | Société des Produits Nestlé S.A. (CH) | 2024-02-22 | — | — | WO | claimed |
| EP-4747367-A1 | NEW ENZYMES FOR THE MANUFACTURING OF 4'-O-METHYLATED PHENOLIC SUBSTANCES | Symrise AG (DE) | 2026-05-27 | — | — | EP | disclosed |
| US-20260048027-A1 | METHYLATED PHLORETIN ANALOGS AS INHIBITORS OF SGLT2 | NESTLE SA (CH) | 2026-02-19 | — | — | US | disclosed |
| EP-4655410-A2 | O-METHYLATION OF PHENOLIC SUBSTANCES VIA FUNGAL O-METHYLTRANSFERASE | Symrise AG (DE) | 2025-12-03 | — | — | EP | disclosed |
| EP-4572749-A1 | METHYLATED PHLORETIN ANALOGS AS INHIBITORS OF SGLT2 | Société des Produits Nestlé S.A. (CH) | 2025-06-25 | — | — | EP | disclosed |
| CN-119654142-A | Methylated phloretin analogs as inhibitors of SGLT2 | 雀巢产品有限公司 | 2025-03-18 | — | — | CN | disclosed |
| WO-2025017042-A1 | NEW ENZYMES FOR THE MANUFACTURING OF 4'-O-METHYLATED PHENOLIC SUBSTANCES | SYMRISE AG (DE) | 2025-01-23 | — | — | WO | disclosed |
| WO-2025016533-A1 | NEW ENZYMES FOR THE MANUFACTURING OF 4'-O-METHYLATED PHENOLIC SUBSTANCES | SYMRISE AG (DE) | 2025-01-23 | — | — | WO | disclosed |
| WO-2024038011-A1 | METHYLATED PHLORETIN ANALOGS AS INHIBITORS OF SGLT2 | Société des Produits Nestlé S.A. (CH) | 2024-02-22 | — | — | WO | disclosed |
| CN-109890376-A | Composition is used in PGC-1 α activation | 三得利控股株式会社 | 2019-06-14 | — | — | CN | disclosed |
| WO-2017132135-A1 | ESTROGEN RECEPTOR ALPHA COLIGANDS, AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-08-03 | — | — | WO | disclosed |
| US-20170071902-A1 | NOX INHIBITOR AND NFkB INHIBITOR CONTAINING METHOXYFLAVONE | SUNTORY HOLDINGS LIMITED (JP) | 2017-03-16 | — | — | US | disclosed |
| WO-2007115181-A9 | COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF | EASTMAN CHEM CO (US) | 2008-04-03 | — | — | WO | disclosed |
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | EASTMAN CHEMICAL COMPANY | 2007-11-01 | — | — | US | disclosed |
| WO-2007115181-A2 | COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF | EASTMAN CHEMICAL COMPANY (US) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | ABCC4, NCOA4, NR4A3 | NFKB1 1115/4885NFKB2 1419/4885RELA 1175/4885 |
| US-20170071902-A1 | NOX INHIBITOR AND NFkB INHIBITOR CONTAINING METHOXYFLAVONE | NOX1, NFKBIA, NOX5 | NFKB1 9/4885NFKB2 8/4885RELA 13/4885 |
| US-20260048027-A1 | METHYLATED PHLORETIN ANALOGS AS INHIBITORS OF SGLT2 | SLC5A2, SLC5A1, SLC2A1 | NFKB1 4036/4885NFKB2 3494/4885RELA 3925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.