Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.32 |
| ▸ | CHRNG | P07510 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2545081 | 0.84 | LMNA (0.39) | SMN1; SMN2MAPTLMNAALDH1A1GAA | |
| SCHEMBL14661394 | 0.80 | MDM2 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28137954 | 0.80 | GAA (0.35) | SMN1; SMN2MAPTLMNAHPGDALDH1A1 | |
| SCHEMBL5082185 | 0.79 | CES2 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5082189 | 0.79 | CES2 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7882734 | 0.78 | KMT2A (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28435707 | 0.76 | ALDH1A1 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7116479 | 0.76 | KMT2A (0.47) | LMNAALDH1A1KMT2AMEN1GAA | |
| SCHEMBL5084398 | 0.76 | EIF4A3 (0.34) | LMNA | |
| SCHEMBL28187370 | 0.76 | CES2 (0.31) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10913747-B2 | Efficient process for the preparation of sitagliptin through a very effective preparation of the intermediate 2,4,5-trifluorophenylacetic acid | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2021-02-09 | — | — | US | disclosed |
| US-20200157109-A1 | EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN THROUGH A VERY EFFECTIVE PREPARATION OF THE INTERMEDIATE 2,4,5-TRIFLUOROPHENYLACETIC ACID | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2020-05-21 | — | — | US | disclosed |
| EP-3424927-B1 | EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN THROUGH A VERY EFFECTIVE PREPARATION OF THE INTERMEDIATE 2,4,5-TRIFLUOROPHENYLACETIC ACID | FIS FABBRICA ITALIANA SINTETICI SPA (IT) | 2019-04-17 | — | — | EP | disclosed |
| WO-2019007578-A1 | EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN THROUGH A VERY EFFECTIVE PREPARATION OF THE INTERMEDIATE 2,4,5-TRIFLUOROPHENYLACETIC ACID | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2019-01-10 | — | — | WO | disclosed |
| EP-3424927-A1 | EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN THROUGH A VERY EFFECTIVE PREPARATION OF THE INTERMEDIATE 2,4,5-TRIFLUOROPHENYLACETIC ACID | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2019-01-09 | — | — | EP | disclosed |
| WO-2008078350-A2 | PROCESS FOR THE PREPARATION OF FLUOROPHENYLACETIC ACIDS AND DERIVATIVES THEREOF | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157109-A1 | EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN THROUGH A VERY EFFECTIVE PREPARATION OF THE INTERMEDIATE 2,4,5-TRIFLUOROPHENYLACETIC ACID | DPP4, DPP9, DPP7 | PSEN1 2293/4885PSEN2 1443/4885APH1B 1440/4885 |
| US-10913747-B2 | Efficient process for the preparation of sitagliptin through a very effective preparation of the intermediate 2,4,5-trifluorophenylacetic acid | DPP4, DPP9, DPP7 | PSEN1 2293/4885PSEN2 1443/4885APH1B 1440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.