SCHEMBL5084476

SCHEMBL5084476

O=C(Nc1ccccc1-c1cccc(C(F)(F)F)c1)Oc1cn[nH]c1

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.50
CHRM3 P20309 2/20 0.48
PDE4B Q07343 1/20 0.43
TACR1 P25103 1/20 0.42
THRB P10828 1/20 0.42
RORC P51449 1/20 0.41
RORB Q92753 1/20 0.41
RIPK1 Q13546 2/20 0.41
RXFP1 Q9HBX9 2/20 0.41
BRAF P15056 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
NTRK1 P04629 2/20 0.40
TOP2A P11388 1/20 0.39
P2RY1 P47900 1/20 0.39
ROCK2 O75116 1/20 0.38
ROCK1 Q13464 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5087704 0.86 CHRM3 (0.47) ALDH1A1CHRM3PDE4BNPC1RAB9A
SCHEMBL5081617 0.84 CHRM3 (0.47) ALDH1A1CHRM3PDE4B
SCHEMBL5085060 0.81 CHRM3 (0.49) CHRM3NPC1RAB9ANPSR1NTRK1
SCHEMBL4602252 0.80 CHRM3 (0.51) ALDH1A1CHRM3NPC1RAB9ANPSR1
SCHEMBL4780539 0.79 CHRM3 (0.45) CHRM3NPC1RAB9ANPSR1
SCHEMBL4602463 0.77 NPC1 (0.47) ALDH1A1CHRM3NPC1RAB9ANPSR1
SCHEMBL5113247 0.75 ALDH1A1 (0.69) ALDH1A1CHRM3TACR1RORCRORB
SCHEMBL1128131 0.75 CHRM3 (0.47) ALDH1A1CHRM3THRBNPC1RAB9A
SCHEMBL4731375 0.75 CCNE2 (0.40) ALDH1A1CHRM3THRBNPC1RAB9A
SCHEMBL1128158 0.75 NPC1 (0.45) ALDH1A1CHRM3NPC1RAB9ANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1901609-A2 FUNGICIDE MIXTURES BASED ON 3-MONOSUBSTITUTED PYRAZOLE CARBOXYLIC ACID BIPHENYL AMIDES BASF SE (DE) 2008-03-26 EP disclosed
WO-2007003603-A2 FUNGICIDE MIXTURES BASED ON 3-MONOSUBSTITUTED PYRAZOLE CARBOXYLIC ACID BIPHENYL AMIDES BASF AKTIENGESELLSCHAFT (DE) 2007-01-11 WO disclosed