SCHEMBL5087704

SCHEMBL5087704

O=C(Nc1ccccc1-c1cccc(F)c1)Oc1cn[nH]c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 9/20 0.47
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
PDE4B Q07343 2/20 0.40
ROCK2 O75116 2/20 0.39
ALDH1A1 P00352 2/20 0.39
KDM4E B2RXH2 1/20 0.39
CYP1A2 P05177 1/20 0.39
HPGD P15428 1/20 0.39
POLB P06746 1/20 0.39
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
TUBB4A P04350 1/20 0.38
TUBB P07437 1/20 0.38
TUBA3C P0DPH7 1/20 0.38
TUBA1B P68363 1/20 0.38
TUBA4A P68366 1/20 0.38
TUBB4B P68371 1/20 0.38
TUBB3 Q13509 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5081617 0.86 CHRM3 (0.47) CHRM3PDE4BALDH1A1KDM4EMEN1
SCHEMBL5084476 0.86 ALDH1A1 (0.50) CHRM3NPC1RAB9ANPSR1PDE4B
SCHEMBL4602252 0.85 CHRM3 (0.51) CHRM3NPC1RAB9ANPSR1ROCK2
SCHEMBL1128131 0.84 CHRM3 (0.47) CHRM3NPC1RAB9ANPSR1ALDH1A1
SCHEMBL1128158 0.84 NPC1 (0.45) CHRM3NPC1RAB9ANPSR1ALDH1A1
SCHEMBL5085060 0.84 CHRM3 (0.49) CHRM3NPC1RAB9ANPSR1ROCK2
SCHEMBL1561098 0.82 ALDH1A1 (0.47) CHRM3ROCK2ALDH1A1KDM4EPOLB
SCHEMBL4602463 0.81 NPC1 (0.47) CHRM3NPC1RAB9ANPSR1ROCK2
SCHEMBL4780539 0.81 CHRM3 (0.45) CHRM3NPC1RAB9ANPSR1KDM4E
SCHEMBL4731375 0.77 CCNE2 (0.40) CHRM3NPC1RAB9ANPSR1ROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1901609-A2 FUNGICIDE MIXTURES BASED ON 3-MONOSUBSTITUTED PYRAZOLE CARBOXYLIC ACID BIPHENYL AMIDES BASF SE (DE) 2008-03-26 EP disclosed
WO-2007003603-A2 FUNGICIDE MIXTURES BASED ON 3-MONOSUBSTITUTED PYRAZOLE CARBOXYLIC ACID BIPHENYL AMIDES BASF AKTIENGESELLSCHAFT (DE) 2007-01-11 WO disclosed