Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 3/20 | 0.43 |
| ▸ | EBP | Q15125 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5085074 | 1.00 | SIGMAR1 (0.43) | SIGMAR1EBPKCNH2DNM1MEN1 | |
| Hydrochloric Acid SCHEMBL5088002 | 0.97 | SIGMAR1 (0.43) | SIGMAR1EBPKCNH2DNM1MEN1 | |
| Iodide SCHEMBL5088335 | 0.97 | SIGMAR1 (0.43) | SIGMAR1EBPKCNH2DNM1MEN1 | |
| Hydrochloric Acid SCHEMBL5092187 | 0.97 | SIGMAR1 (0.43) | SIGMAR1EBPKCNH2DNM1MEN1 | |
| Iodide SCHEMBL5091310 | 0.97 | SIGMAR1 (0.43) | SIGMAR1EBPKCNH2DNM1MEN1 | |
| SCHEMBL9947764 | 0.77 | TAAR1 (0.45) | TP53SMN1; SMN2 | |
| Bromide SCHEMBL5450415 | 0.77 | SLC6A2 (0.47) | KCNH2DNM1MEN1KMT2ATP53 | |
| Bromide SCHEMBL23413508 | 0.77 | DNM1 (0.46) | DNM1 | |
| Bromide SCHEMBL4347932 | 0.77 | DNM1 (0.46) | DNM1 | |
| SCHEMBL2782164 | 0.77 | SLC6A2 (0.45) | SIGMAR1KCNH2DNM1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214386-A1 | Stability; easily separated from solution; surface treatment of catalyst with Group seven compound; reacting epoxide with carbon dioxide | NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 2008-09-04 | — | — | US | disclosed |