Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 3/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.36 |
| ▸ | ATR | Q13535 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5080636 | 0.88 | IGF1R (0.48) | IGF1RCSF1RTNK2ATRADORA2A | |
| SCHEMBL5086140 | 0.85 | TNK2 (0.45) | IGF1RF2PLGPRSS1TNK2 | |
| SCHEMBL5086965 | 0.85 | IGF1R (0.43) | IGF1RTNK2MEN1KMT2ATGFBR1 | |
| SCHEMBL5083787 | 0.82 | TNK2 (0.42) | IGF1RTNK2ADORA2AADORA1 | |
| SCHEMBL400115 | 0.79 | IGF1R (0.65) | IGF1RTNK2 | |
| SCHEMBL3040790 | 0.79 | IGF1R (0.51) | IGF1RTNK2ATRADORA2AADORA1 | |
| SCHEMBL5087010 | 0.78 | IGF1R (0.39) | IGF1RTNK2ATRMEN1KMT2A | |
| SCHEMBL401018 | 0.77 | TNK2 (0.38) | IGF1RTNK2RAB9AMAPT | |
| SCHEMBL1566947 | 0.77 | TNK2 (0.38) | IGF1RTNK2RAB9AMAPT | |
| SCHEMBL5262952 | 0.76 | IGF1R (0.39) | IGF1RADORA2AADORA1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |