SCHEMBL5085632

SCHEMBL5085632

CC(C)(COC(=O)c1ccccc1Br)OC(=O)c1ccccc1Br

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.46
NPC1 O15118 2/20 0.46
HPGD P15428 1/20 0.46
KMT2A Q03164 3/20 0.45
ALDH1A1 P00352 7/20 0.44
GAA P10253 2/20 0.44
MAPT P10636 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
TSHR P16473 3/20 0.43
MEN1 O00255 1/20 0.43
HTT P42858 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.41
KDM4E B2RXH2 1/20 0.40
MITF O75030 1/20 0.40
NOD1 Q9Y239 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1784955 0.80 KMT2A (0.49) RAB9ANPC1HPGDKMT2AALDH1A1
SCHEMBL488979 0.80 KMT2A (0.56) RAB9ANPC1HPGDKMT2AALDH1A1
SCHEMBL408906 0.76 TSHR (0.74) RAB9ANPC1HPGDKMT2AALDH1A1
SCHEMBL4828257 0.76 KMT2A (0.46) RAB9ANPC1HPGDKMT2AALDH1A1
SCHEMBL19574803 0.75 ALDH1A1 (0.53) NPC1HPGDKMT2AALDH1A1TSHR
Bromide SCHEMBL15544606 0.75 TSHR (0.71) RAB9ANPC1HPGDKMT2AALDH1A1
SCHEMBL28628629 0.75 TSHR (0.71) RAB9ANPC1HPGDKMT2AALDH1A1
SCHEMBL20402975 0.74 ALDH1A1 (0.64) ALDH1A1TSHRL3MBTL1KDM4E
SCHEMBL5664162 0.74 ALDH1A1 (0.46) RAB9ANPC1HPGDKMT2AALDH1A1
SCHEMBL1785409 0.73 MAPK1 (0.65) RAB9ANPC1KMT2AALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3486263-A2 SELF-LIMITING CATALYST COMPOSITION WITH NO SILANE W.R. Grace & CO. - CONN. (US) 2019-05-22 EP disclosed
EP-2185600-B1 SELF-LIMITING CATALYST COMPOSITION WITH NO SILANE GRACE W R & CO (US) 2018-10-31 EP disclosed
US-9796796-B2 Self-limiting catalyst composition with No silane W. R. GRACE & CO.-CONN. (US) 2017-10-24 US disclosed
EP-1666505-B1 CATALYST COMPONENTS CATALYSTS FOR OLEFINIC POLYMERIZATION AND THE USE THEREOF CHINA PETROLEUM & CHEMICAL (CN) 2016-03-23 EP disclosed
US-20130109789-A1 OLEFIN POLYMERIZATION CATALYST, PROCESS FOR PRODUCING OLEFIN POLYMER, POLYPROPYLENE RESIN COMPOSITION AND ARTICLE COMPRISING THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-02 US disclosed
US-7332455-B2 Catalyst component and catalyst for olefin polymerization as well as use thereof CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2008-02-19 US disclosed
EP-1666505-A1 CATALYST COMPONENTS CATALYSTS FOR OLEFINIC POLYMERIZATION AND THE USE THEREOF China Petroleum & Chemical Corporation (CN) 2006-06-07 EP disclosed
US-20050119427-A1 Catalyst component and catalyst for olefin polymerization as well as use thereof BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2005-06-02 US disclosed