Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5085945 | 0.86 | ALDH1A1 (0.41) | MTNR1AMTNR1BALDH1A1ROCK2ROCK1 | |
| SCHEMBL5093164 | 0.84 | KDM4E (0.45) | MTNR1AALDH1A1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL1963245 | 0.81 | RXFP1 (0.41) | MTNR1AMTNR1BALDH1A1ROCK2ROCK1 | |
| SCHEMBL1964674 | 0.75 | KDR (0.44) | ALDH1A1KDM4EKDRSMN1; SMN2DRD2 | |
| SCHEMBL1962083 | 0.72 | CACNA1B (0.46) | ALDH1A1KDM4EHSD17B10SMN1; SMN2LMNA | |
| SCHEMBL7956961 | 0.71 | ALDH1A1 (0.58) | ALDH1A1KDM4ESMN1; SMN2CYP2C19HSP90AA1 | |
| SCHEMBL1963248 | 0.71 | CDC25B (0.44) | MTNR1AMTNR1BALDH1A1ROCK2KDM4E | |
| SCHEMBL1964231 | 0.70 | HRH3 (0.52) | ALDH1A1KDM4EHSD17B10KDRSMN1; SMN2 | |
| SCHEMBL1961731 | 0.70 | KDR (0.45) | ALDH1A1KDM4EKDRSMN1; SMN2HRH3 | |
| SCHEMBL1964172 | 0.70 | BRPF1 (0.47) | ALDH1A1KDM4EKDRSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919892-A2 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORPORATION (US) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007027527-A2 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORPORATION (US) | 2007-03-08 | — | — | WO | disclosed |