Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5093175 | 0.87 | KDM4E (0.43) | ALDH1A1KDM4EHSD17B10KMT2AMEN1 | |
| SCHEMBL5085941 | 0.86 | MTNR1A (0.41) | ALDH1A1KDM4EHSD17B10HPGDPTPN1 | |
| SCHEMBL1963248 | 0.81 | CDC25B (0.44) | ALDH1A1KDM4EHSD17B10KMT2AMEN1 | |
| SCHEMBL1964675 | 0.76 | CDC25B (0.46) | ALDH1A1KDM4EKMT2AMEN1HPGD | |
| SCHEMBL1961738 | 0.72 | CDC25B (0.45) | ALDH1A1KDM4EKMT2AMEN1HPGD | |
| SCHEMBL1962084 | 0.71 | MEN1 (0.46) | ALDH1A1KDM4EKMT2AMEN1HPGD | |
| SCHEMBL1964234 | 0.71 | HRH3 (0.50) | ALDH1A1KDM4EKMT2AMEN1HPGD | |
| SCHEMBL1963245 | 0.71 | RXFP1 (0.41) | ALDH1A1KDM4EHSD17B10MTNR1AMTNR1B | |
| SCHEMBL5093164 | 0.71 | KDM4E (0.45) | ALDH1A1KDM4EHSD17B10KMT2AMEN1 | |
| SCHEMBL1964177 | 0.70 | BRPF1 (0.43) | ALDH1A1KDM4EKMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919892-A2 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORPORATION (US) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007027527-A2 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORPORATION (US) | 2007-03-08 | — | — | WO | disclosed |