Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.50 |
| ▸ | EEF2K | O00418 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | CTSA | P10619 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3663293 | 0.86 | FAAH (0.58) | FAAHSMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL16680706 | 0.86 | SMN1; SMN2 (0.48) | FAAHSMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL5085765 | 0.85 | SMN1; SMN2 (0.50) | FAAHSMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL14040614 | 0.85 | SMN1; SMN2 (0.57) | FAAHSMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL844472 | 0.85 | SMN1; SMN2 (0.57) | FAAHSMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL4265545 | 0.84 | SMN1; SMN2 (0.50) | FAAHSMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL2320404 | 0.84 | FAAH (0.59) | FAAHSMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL5181827 | 0.84 | KMT2A (0.53) | FAAHSMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL4097623 | 0.84 | SMN1; SMN2 (0.48) | FAAHSMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL2358938 | 0.82 | MMP12 (0.48) | FAAHSMN1; SMN2NPC1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008101840-A1 | COMBINATION OF ERLOTINIB AND MEK-INHIBITORS FOR INHIBITING PROLIFERATION OF TUMOR CELLS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-28 | — | — | WO | disclosed |