Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.55 |
| ▸ | BCHE | P06276 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780466 | 0.79 | ACHE (0.66) | ACHEBCHEALDH1A1HSD17B10KDM4E | |
| SCHEMBL4782557 | 0.75 | ACHE (0.53) | ACHEBCHEALDH1A1HSD17B10KDM4E | |
| SCHEMBL10654315 | 0.73 | ACHE (0.62) | ACHEBCHEALDH1A1HSD17B10KDM4E | |
| SCHEMBL9547692 | 0.71 | ACHE (1.00) | ACHEBCHEALDH1A1HSD17B10KDM4E | |
| SCHEMBL10470175 | 0.70 | ACHE (0.61) | ACHEBCHEALDH1A1HSD17B10KDM4E | |
| SCHEMBL9165440 | 0.70 | ACHE (0.50) | ACHEBCHEALDH1A1HSD17B10KDM4E | |
| SCHEMBL8781795 | 0.68 | ACHE (0.62) | ACHEBCHEALDH1A1HSD17B10KDM4E | |
| 7-Hydroxytacrine SCHEMBL9547668 | 0.68 | ACHE (1.00) | ACHEBCHEALDH1A1HSD17B10KDM4E | |
| SCHEMBL9547653 | 0.68 | ACHE (1.00) | ACHEBCHEALDH1A1HSD17B10KDM4E | |
| SCHEMBL10620451 | 0.67 | ACHE (0.61) | ACHEBCHEALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080044390-A1 | Methods and compositions for the treatment of neurodegenerative disorders | CHDI, INCORPORATED | 2008-02-21 | — | — | US | disclosed |
| EP-0589900-A1 | ALZHEIMER'S DISEASE TREATMENT WITH TACRINE METABOLITES | INSTITUTE OF PSYCHIATRY (GB) | 1994-04-06 | — | — | EP | disclosed |
| WO-1992022534-A1 | ALZHEIMER'S DISEASE TREATMENT WITH TACRINE METABOLITES | MARCHBANKS ROGER MICHAEL (GB) | 1992-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080044390-A1 | Methods and compositions for the treatment of neurodegenerative disorders | HTT, SNCA, NLN | ACHE 16/4885BCHE 29/4885ALDH1A1 2348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.