Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 1.00 |
| ▸ | BCHE | P06276 | 5/20 | 0.59 |
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.59 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.59 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.59 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.59 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.59 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.59 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.59 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.59 |
| ▸ | APP | P05067 | 1/20 | 0.59 |
| ▸ | FABP1 | P07148 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9547653 | 0.88 | ACHE (1.00) | ACHEBCHETSHRALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL9547702 | 0.87 | ACHE (0.97) | ACHEBCHETSHRALDH1A1CYP1A2 | |
| Tacrine SCHEMBL2828 | 0.74 | ACHE (1.00) | ACHEBCHETSHRALDH1A1CYP1A2 | |
| SCHEMBL30063279 | 0.74 | ACHE (1.00) | ACHEBCHETSHRALDH1A1CYP1A2 | |
| SCHEMBL5047992 | 0.74 | ACHE (1.00) | ACHEBCHETSHRALDH1A1CYP1A2 | |
| Tacrine SCHEMBL29681895 | 0.74 | ACHE (1.00) | ACHEBCHETSHRALDH1A1CYP1A2 | |
| Tacrine SCHEMBL7714835 | 0.74 | ACHE (1.00) | ACHEBCHETSHRALDH1A1CYP1A2 | |
| Tacrine SCHEMBL29594645 | 0.74 | ACHE (1.00) | ACHEBCHETSHRALDH1A1CYP1A2 | |
| Tacrine SCHEMBL28031239 | 0.74 | ACHE (0.90) | ACHEBCHETSHRALDH1A1CYP1A2 | |
| SCHEMBL4780466 | 0.73 | ACHE (0.66) | ACHEBCHETSHRALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369388-B1 | HYDROXY-1,2,3,4-TETRAHYDROAMINOACRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-05-19 | — | — | EP | disclosed |
| EP-0369388-A1 | Hydroxy-1,2,3,4-tetrahydroaminoacridines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-05-23 | — | — | EP | disclosed |