SCHEMBL5086477

SCHEMBL5086477

CCCc1c[c]c(Br)c(-c2cccc([N+](=O)[O-])c2)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.51
MAPT P10636 4/20 0.42
GAA P10253 1/20 0.42
RXFP1 Q9HBX9 1/20 0.42
AKR1C3 P42330 4/20 0.42
AKR1C2 P52895 4/20 0.42
MAPK1 P28482 1/20 0.39
PDE4A P27815 1/20 0.39
PDE4B Q07343 1/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
TSHR P16473 3/20 0.38
LMNA P02545 1/20 0.38
ALOX5 P09917 1/20 0.37
MAOB P27338 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5086481 0.78 ALDH1A1 (0.48) ALDH1A1MAPTGAARXFP1AKR1C3
SCHEMBL7445710 0.77 ALDH1A1 (0.52) ALDH1A1MAPTGAAAKR1C3AKR1C2
SCHEMBL5085691 0.73 PTPN5 (0.34) MAOB
SCHEMBL4427520 0.73 TSHR (0.35) ALDH1A1MAPTGAARXFP1AKR1C3
SCHEMBL680656 0.72 TSHR (0.62) ALDH1A1MAPTSMN1; SMN2TSHRLMNA
SCHEMBL7433808 0.71 SKP2 (0.47) ALDH1A1MAPTGAAAKR1C3AKR1C2
SCHEMBL7439484 0.71 PDE4A (0.71) ALDH1A1MAPTPDE4APDE4BNPC1
SCHEMBL7441450 0.70 KCNH2 (0.45) ALDH1A1MAPTGAAAKR1C3AKR1C2
Dinitrophenylene SCHEMBL27675225 0.70 CYP1A2 (0.59) ALDH1A1NPC1RAB9ASMN1; SMN2TSHR
SCHEMBL12826413 0.67 TSHR (0.54) ALDH1A1MAPTGAANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008091594-A2 FUNGICIDAL MIXTURES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-07-31 WO disclosed