Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 11/20 | 0.45 |
| ▸ | IGF1R | P08069 | 3/20 | 0.40 |
| ▸ | F2 | P00734 | 5/20 | 0.40 |
| ▸ | PLG | P00747 | 3/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5084882 | 0.88 | IGF1R (0.48) | TNK2IGF1R | |
| SCHEMBL5083298 | 0.85 | IGF1R (0.40) | TNK2IGF1RF2PLGPRSS1 | |
| SCHEMBL5086965 | 0.85 | IGF1R (0.43) | TNK2IGF1RKDM4EALDH1A1HPGD | |
| SCHEMBL5086253 | 0.81 | TNK2 (0.50) | TNK2IGF1R | |
| SCHEMBL398633 | 0.79 | TNK2 (0.71) | TNK2IGF1R | |
| SCHEMBL3040790 | 0.79 | IGF1R (0.51) | TNK2IGF1RHPGD | |
| SCHEMBL5081252 | 0.78 | TNK2 (0.42) | TNK2IGF1R | |
| SCHEMBL401018 | 0.77 | TNK2 (0.38) | TNK2IGF1RKDM4EALDH1A1 | |
| SCHEMBL1566947 | 0.77 | TNK2 (0.38) | TNK2IGF1RKDM4EALDH1A1 | |
| SCHEMBL5262952 | 0.76 | IGF1R (0.39) | IGF1RKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |