SCHEMBL5087451

SCHEMBL5087451

FC(F)(F)c1ccccc1P(c1ccccc1C(F)(F)F)c1ccccc1C(F)(F)F

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.41
TDP1 Q9NUW8 2/20 0.41
POLB P06746 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
IDO1 P14902 2/20 0.39
LMNA P02545 2/20 0.38
GAA P10253 1/20 0.38
TSHR P16473 1/20 0.38
HSD11B1 P28845 1/20 0.36
NFKB1 P19838 1/20 0.36
KIF11 P52732 1/20 0.36
HTR2C P28335 2/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
CA2 P00918 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
MAPT P10636 1/20 0.34
CYP2C9 P11712 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15661102 0.97 ALDH1A1 (0.40) ALDH1A1TDP1POLBL3MBTL1IDO1
SCHEMBL15660242 0.91 HSD11B1 (0.40) ALDH1A1TDP1POLBL3MBTL1IDO1
SCHEMBL15732306 0.87 HSD11B1 (0.38) ALDH1A1TDP1POLBL3MBTL1IDO1
SCHEMBL10792614 0.86 TDP1 (0.46) ALDH1A1TDP1POLBL3MBTL1IDO1
SCHEMBL9854376 0.86 TDP1 (0.46) ALDH1A1TDP1POLBL3MBTL1IDO1
SCHEMBL30085602 0.86 TDP1 (0.46) ALDH1A1TDP1POLBL3MBTL1IDO1
SCHEMBL30637851 0.84 TDP1 (0.44) ALDH1A1TDP1POLBL3MBTL1IDO1
Hydrochloric Acid SCHEMBL10791016 0.83 TDP1 (0.42) ALDH1A1TDP1POLBL3MBTL1IDO1
Bromide SCHEMBL10795463 0.83 TDP1 (0.42) ALDH1A1TDP1POLBL3MBTL1IDO1
Hydrochloric Acid SCHEMBL10795466 0.83 TDP1 (0.42) ALDH1A1TDP1POLBL3MBTL1IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110079867-B On-DNA wittig reaction method in DNA coding compound library and prepared On-DNA olefin compound 上海药明康德新药开发有限公司 2022-01-04 CN claimed
US-20140323671-A1 PROCESS FOR METATHESIS OF OLEFINS OBTAINED FROM FISCHER-TROPSCH FRACTIONS USING A RUTHENIUM COMPLEX COMPRISING A DISSYMMETRICAL N-HETEROCYCLIC DIAMINOCARBENE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2014-10-30 US claimed
US-20140235913-A1 PROCESS FOR METATHESIS OF OLEFINS OBTAINED FROM FISCHER-TROPSCH FRACTIONS USING A RUTHENIUM COMPLEX COMPRISING A SYMMETRIC N-HETEROCYCLIC DIAMINOCARBENE IFP Energies Nouvelles (FR) 2014-08-21 US claimed
WO-2013079820-A1 METHOD FOR METATHESIZING LINEAR ALPHA OLEFINS USING A RUTHENIUM COMPLEX COMPRISING AN ASYMMETRICAL N-HETEROCYCLIC CARBENE IFP Energies Nouvelles (FR) 2013-06-06 WO claimed
EP-1034196-A1 CATALYST AND METHODS FOR POLYMERIZING CYCLOOLEFINS THE B.F. GOODRICH COMPANY (US) 2000-09-13 EP claimed
WO-2000020472-A1 CATALYST AND METHODS FOR POLYMERIZING CYCLOOLEFINS THE B.F. GOODRICH COMPANY (US) 2000-04-13 WO claimed
EP-4685173-A1 A METHOD FOR PREPARING A POLYMER MATERIAL FROM A CYCLIC OLEFIN COMPOSITION WITH CONTROLLED VISCOSITY VIPO FRANCE SAS (FR) 2026-01-28 EP disclosed
US-11932596-B2 Fluorovinyl ether compound DAIKIN INDUSTRIES, LTD. (JP) 2024-03-19 US disclosed
EP-4101892-B1 COMPOSITION, THERMALLY CONDUCTIVE MATERIAL, THERMALLY CONDUCTIVE SHEET, AND DEVICE WITH THERMALLY CONDUCTIVE LAYER FUJIFILM CORP (JP) 2024-02-21 EP disclosed
WO-2024017654-A1 COMPOSITE MATERIAL COMPRISING A ROMP-DERIVED POLYOLEFIN EMBEDDED IN A SILICONE MATRIX VIPO FRANCE SAS (FR) 2024-01-25 WO disclosed
EP-4310148-A1 COMPOSITE MATERIAL COMPRISING A ROMP-DERIVED POLYOLEFIN EMBEDDED IN A SILICONE MATRIX Demeta (FR) 2024-01-24 EP disclosed
EP-3643694-B1 METHOD FOR PRODUCING BUTADIENE COMPOUND DAIKIN IND LTD (JP) 2023-11-15 EP disclosed
US-20230272272-A1 Surface Treatment Of Quantum Dots UNITED STATES DEPARTMENT OF ENERGY 2023-08-31 US disclosed
EP-1607414-A1 A catalytic composition and its preparation and use for preparing polymers from ethylenically unsaturated monomers ROHM AND HAAS COMPANY (US) 2005-12-21 EP disclosed
US-20050277569-A1 Catalytic composition and its preparation and use for preparing polymers from ethylenically unsaturated monomers ROHM AND HAAS COMPANY 2005-12-15 US disclosed
US-20050277749-A1 Catalytic composition and its preparation and use for preparing polymers from ethylenically unsaturated monomers ROHM AND HAAS COMPANY 2005-12-15 US disclosed
US-20050043494-A1 Catalytic composition and its preparation and use for preparing polymers from ethylenically unsaturated monomers ROHM AND HAAS COMPANY 2005-02-24 US disclosed
EP-1508577-A1 A catalytic composition and its preparation and use for preparing polymers from ethylenically unsaturated monomers ROHM AND HAAS COMPANY (US) 2005-02-23 EP disclosed
EP-0248951-A2 Process for producing branched carbonylation products from alpha unsaturated olefins ATLANTIC RICHFIELD COMPANY (US) 1987-12-16 EP disclosed
US-4612390-A PHOSPHINE PALLADIUM CATALYST ATLANTIC RICHFIELD COMPANY (US) 1986-09-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11932596-B2 Fluorovinyl ether compound RB1, AFF1, AFF2 ALDH1A1 1360/4885TDP1 3018/4885POLB 3525/4885
US-20140235913-A1 PROCESS FOR METATHESIS OF OLEFINS OBTAINED FROM FISCHER-TROPSCH FRACTIONS USING A RUTHENIUM COMPLEX COMPRISING A SYMMETRIC N-HETEROCYCLIC DIAMINOCARBENE ODC1, DDT, FDFT1 ALDH1A1 460/4885TDP1 2156/4885POLB 1705/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.