Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GRM6 | O15303 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28011450 | 0.76 | VCAM1 (0.44) | VCAM1TDP1ALDH1A1KDM4EKMT2A | |
| SCHEMBL1522100 | 0.76 | TDP1 (0.50) | VCAM1TDP1ALDH1A1KDM4EKMT2A | |
| SCHEMBL2238161 | 0.76 | ALDH1A1 (0.38) | VCAM1TDP1ALDH1A1KDM4EKMT2A | |
| SCHEMBL30832623 | 0.75 | PDE10A (0.51) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL126343 | 0.75 | PDE10A (0.51) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL27912760 | 0.74 | TDP1 (0.48) | TDP1ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL7676817 | 0.73 | TDP1 (0.47) | VCAM1TDP1ALDH1A1KDM4EKMT2A | |
| SCHEMBL27734949 | 0.73 | TDP1 (0.47) | TDP1ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL3938268 | 0.72 | TDP1 (0.56) | TDP1ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL3065093 | 0.72 | RAB9A (0.39) | ALDH1A1KDM4EKMT2AMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962847-A2 | PYRIDINYL SULFONAMIDE MODULATORS OF CHEMOKINE RECEPTORS | GLAXO GROUP LIMITED (GB) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067875-A2 | PYRIDINYL SULFONAMIDE MODULATORS OF CHEMOKINE RECEPTORS | GLAXO GROUP LIMTED (GB) | 2007-06-14 | — | — | WO | disclosed |