Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.47 |
| ▸ | SUCNR1 | Q9BXA5 | 5/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 4/20 | 0.43 |
| ▸ | CA1 | P00915 | 4/20 | 0.43 |
| ▸ | CA2 | P00918 | 4/20 | 0.43 |
| ▸ | CA9 | Q16790 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3811492 | 1.00 | ITGB3 (0.51) | ITGB3ITGA2BCTSSCTSKGPR88 | |
| SCHEMBL844327 | 0.94 | CTSS (0.50) | ITGB3ITGA2BCTSSCTSKGPR88 | |
| SCHEMBL844326 | 0.94 | CTSS (0.50) | ITGB3ITGA2BCTSSCTSKGPR88 | |
| SCHEMBL3375054 | 0.91 | SUCNR1 (0.48) | ITGB3ITGA2BCTSSCTSKGPR88 | |
| SCHEMBL3375051 | 0.91 | SUCNR1 (0.48) | ITGB3ITGA2BCTSSCTSKGPR88 | |
| SCHEMBL11595296 | 0.88 | CTSS (0.51) | ITGB3ITGA2BCTSSCTSKGPR88 | |
| SCHEMBL1349362 | 0.88 | CTSS (0.51) | ITGB3ITGA2BCTSSCTSKGPR88 | |
| SCHEMBL1349363 | 0.88 | CTSS (0.51) | ITGB3ITGA2BCTSSCTSKGPR88 | |
| SCHEMBL7271316 | 0.87 | POLB (0.53) | ITGB3ITGA2BCTSSCTSKGPR88 | |
| SCHEMBL844276 | 0.86 | CTSS (0.50) | ITGB3ITGA2BCTSSCTSKGPR88 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791837-B1 | SUBSTITUTED HYDANTOINS FOR THE TREATMENT OF CANCER | HOFFMANN LA ROCHE (CH) | 2009-08-19 | — | — | EP | disclosed |
| US-7371869-B2 | Substituted hydantoins | HOFFMANN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | disclosed |
| US-20060063814-A1 | Substituted hydantoins | GOODNOW ROBERT A JR | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063814-A1 | Substituted hydantoins | HNMT, MAPK6, KYNU | ITGB3 4727/4885ITGA2B 4585/4885CTSS 1158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.