Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | PAM | P19021 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20583636 | 0.91 | LMNA (0.50) | TSHRALDH1A1L3MBTL1LMNAMEN1 | |
| SCHEMBL9528323 | 0.86 | CA12 (0.47) | CA12CA1CA7CA14TSHR | |
| SCHEMBL1346095 | 0.85 | TSHR (0.56) | CA12CA1CA7CA14TSHR | |
| SCHEMBL27053828 | 0.85 | HPGD (0.49) | ALDH1A1L3MBTL1LMNAMEN1KMT2A | |
| SCHEMBL25354116 | 0.83 | MAPT (0.51) | TSHRALDH1A1L3MBTL1LMNAMEN1 | |
| SCHEMBL31048202 | 0.83 | L3MBTL1 (0.44) | ALDH1A1L3MBTL1KDM4ELMNAMEN1 | |
| SCHEMBL7058420 | 0.83 | TDP1 (0.50) | CA12CA1CA7CA14ATM | |
| SCHEMBL23043726 | 0.83 | KDM4E (0.49) | MAPK1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL28515878 | 0.82 | CES1 (0.47) | CA12CA1CA7CA14TSHR | |
| SCHEMBL27520004 | 0.82 | TSHR (0.53) | CA12CA1CA7CA14TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339976-A1 | KRAS G12D INHIBITORS | Mirati Therapeutics, Inc. | 2023-10-26 | — | — | US | disclosed |
| US-7317009-B2 | Pyrrolopyridazine derivatives | ASTELLAS PHARMA INC. (JP) | 2008-01-08 | — | — | US | disclosed |
| US-7153854-B2 | Pyrrolopyridazine derivatives | ASTELLAS PHARMA INC. (JP) | 2006-12-26 | — | — | US | disclosed |
| US-20060270678-A1 | Pyrrolopyridazine derivatives | ASTELLAS PHARMA INC. (JP) | 2006-11-30 | — | — | US | disclosed |
| EP-1581535-A1 | PYRROLOPYRIDAZINE DERIVATIVES | Astellas Pharma Inc. (JP) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004063197-A1 | PYRROLOPYRIDAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-07-29 | — | — | WO | disclosed |
| WO-2003035615-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2003-05-01 | — | — | WO | disclosed |
| WO-2003035616-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2003-05-01 | — | — | WO | disclosed |
| US-5945559-A | REACTING AN ACETOACETIC ESTER WITH A CALCIUM, BARIUM OR STRONTIUM COMPOUND IN SOLVENT AND ACYLATION WITH A CARBOXYLICACID CHLORIDE, AND DEACYLATION WITH ALCOHOLS | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1999-08-31 | — | — | US | disclosed |
| US-5859283-A | TERTIARY-BUTYL 3-CYCLOALKYL-3-OXOPROPIONATE | RHONE-POULENC AGRICULTURE LIMITED (GB) | 1999-01-12 | — | — | US | disclosed |
| US-5747424-A | HEATING AN AROMATIC DIKETONE WITH A SALT OF HYDROXYLAMINE IN A SOLVENT | RHONE-POULENC AGRICULTURE LTD. (GB) | 1998-05-05 | — | — | US | disclosed |
| US-5656573-A | Herbicidal 4-substituted isoxazoles | RHONE-POULENC AGRICULTURE LTD. (GB) | 1997-08-12 | — | — | US | disclosed |
| US-5650533-A | Intermediates to herbicidal 4-substituted isoxazoles | RHONE-POULENC AGRICULTURE LTD. (GB) | 1997-07-22 | — | — | US | disclosed |
| EP-0418175-B1 | Isoxazoles herbicides | RHONE POULENC AGRICULTURE (GB) | 1996-07-17 | — | — | EP | disclosed |
| EP-0416857-B1 | Process for producing 4-halogeno-2-alkoxyimino-3-oxo fatty acid | WAKO PURE CHEM IND LTD (JP) | 1995-01-11 | — | — | EP | disclosed |
| US-5095149-A | PROCESS FOR PRODUCING 4-HALOGENO-2-ALKOXYIMINO-3-OXO FATTY ACID | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-10 | — | — | US | disclosed |
| EP-0418175-A2 | Isoxazoles herbicides | RHONE POULENC AGRICULTURE LTD. (GB) | 1991-03-20 | — | — | EP | disclosed |
| EP-0416857-A2 | Process for producing 4-halogeno-2-alkoxyimino-3-oxo fatty acid | WAKO PURE CHEMICAL INDUSTRIES LTD (JP) | 1991-03-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270678-A1 | Pyrrolopyridazine derivatives | PDE4A, PDE5A, PDE12 | CA12 3071/4885CA1 2226/4885CA7 1858/4885 |
| US-20230339976-A1 | KRAS G12D INHIBITORS | KRAS, NRAS, HRAS | CA12 3750/4885CA1 3229/4885CA7 1898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.