Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | PAM | P19021 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5089657 | 0.86 | CA12 (0.47) | CA12CA1CA7CA14TSHR | |
| SCHEMBL1346095 | 0.85 | TSHR (0.56) | CA12CA1CA7CA14TSHR | |
| SCHEMBL27520004 | 0.82 | TSHR (0.53) | CA12CA1CA7CA14TSHR | |
| SCHEMBL9551634 | 0.80 | CRHBP (0.60) | ATMALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL28954433 | 0.78 | TSHR (0.49) | CA12CA1CA7CA14TSHR | |
| SCHEMBL394244 | 0.78 | ALDH1A1 (0.56) | CA12CA1CA7CA14ATM | |
| SCHEMBL20583636 | 0.78 | LMNA (0.50) | TSHRALDH1A1L3MBTL1LMNAMEN1 | |
| SCHEMBL28872153 | 0.77 | GAA (0.53) | CA12CA1CA7CA14ATM | |
| SCHEMBL7058420 | 0.77 | TDP1 (0.50) | CA12CA1CA7CA14ATM | |
| SCHEMBL14719815 | 0.76 | ALDH1A1 (0.52) | ALDH1A1MAPK1L3MBTL1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0531382-A1 | N-SUBSTITUTED-1,2,4-TRIAZOLONE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1993-03-17 | — | — | EP | claimed |