Sugi Predict

Sugi Predict / Compounds / SCHEMBL508980

SCHEMBL508980

SCHEMBL508980

CN1CCN(C2CCCCC2)CC1

nearest known ligand 0.74

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ PHGDH O43175 1/20 0.47
▸ MGLL Q99685 1/20 0.47
▸ LMNA P02545 2/20 0.44
▸ ALDH1A1 P00352 1/20 0.44
▸ TP53 P04637 1/20 0.44
▸ MAPT P10636 1/20 0.44
▸ MEN1 O00255 2/20 0.42
▸ KMT2A Q03164 2/20 0.42
▸ POLB P06746 1/20 0.42
▸ HSD17B10 Q99714 1/20 0.42
▸ SIGMAR1 Q99720 3/20 0.42
▸ SLC18A3 Q16572 1/20 0.41
▸ ABCB1 P08183 2/20 0.41
▸ L3MBTL3 Q96JM7 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20080914 1.00 PHGDH (0.47) PHGDHMGLLLMNAALDH1A1TP53
SCHEMBL2056148 1.00 PHGDH (0.47) PHGDHMGLLLMNAALDH1A1TP53
SCHEMBL16716747 1.00 PHGDH (0.47) PHGDHMGLLLMNAALDH1A1TP53
SCHEMBL2321741 0.97 PHGDH (0.43) PHGDHMGLLLMNAALDH1A1TP53
SCHEMBL1645820 0.97 PHGDH (0.43) PHGDHMGLLLMNAALDH1A1TP53
SCHEMBL13942544 0.93 KDM4E (0.47) PHGDHMGLLLMNAALDH1A1TP53
SCHEMBL81246 0.92 L3MBTL3 (0.41) PHGDHMGLLLMNAALDH1A1TP53
SCHEMBL13330131 0.91 L3MBTL3 (0.50) PHGDHMGLLLMNAALDH1A1TP53
SCHEMBL14947655 0.90 KDM4E (0.48) PHGDHMGLLLMNAALDH1A1TP53
Bicarbonate SCHEMBL1828583 0.89 POLB (0.49) PHGDHMGLLLMNAALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 281 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104411311-A Substituted benzamides and their use UNIV LELAND STANFORD JUNIOR 2015-03-11 — — CN claimed
EP-2300370-B1 SYNTHESIS OF MSE-FRAMEWORK TYPE MOLECULAR SIEVES EXXONMOBIL RES & ENG CO (US) 2014-06-18 — — EP claimed
CN-102066259-B Synthesis and use of MSE framework type molecular sieves EXXONMOBIL RES & ENG CO 2014-01-15 — — CN claimed
CN-103327972-A Substituted benzamides and their uses UNIV LELAND STANFORD JUNIOR 2013-09-25 — — CN claimed
US-20120053345-A1 Indazole Compounds ABBOTT LABORATORIES (US) 2012-03-01 — — US claimed
JP-2011524848-A — — 2011-09-08 — — JP claimed
US-8008481-B2 Indazole compounds ABBVIE INC. 2011-08-30 — — US claimed
CN-102066259-A Synthesis and use of MSE framework type molecular sieves EXXONMOBIL RES & ENG CO 2011-05-18 — — CN claimed
EP-2300370-A2 SYNTHESIS AND USE OF MSE-FRAMEWORK TYPE MOLECULAR SIEVES ExxonMobil Research and Engineering Company (US) 2011-03-30 — — EP claimed
US-20090318696-A1 Synthesis and use of MSE-framework type molecular sieves EXXONMOBIL RESEARCH AND ENGINEERING COMPANY 2009-12-24 — — US claimed
WO-2009154783-A2 SYNTHESIS AND USE OF MSE-FRAMEWORK TYPE MOLECULAR SIEVES EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) 2009-12-23 — — WO claimed
EP-2001480-A2 INDAZOLE COMPOUNDS Abbott Laboratories (US) 2008-12-17 — — EP claimed
US-20070282101-A1 Indazole compounds ABBVIE INC. 2007-12-06 — — US claimed
WO-2007117465-A2 INDAZOLE COMPOUNDS ABBOTT LABORATORIES (US) 2007-10-18 — — WO claimed
EP-4400497-A1 3CLPRO PROTEASE INHIBITOR Shanghai Qilu Pharmaceutical Research and Development Centre Ltd. (CN) 2024-07-17 — — EP disclosed
US-20240025887-A1 THIENYL AND CYCLOALKYL AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF SINAI HEALTH SYSTEM (CA) 2024-01-25 — — US disclosed
US-20240016775-A1 ANTI-CORONAVIRUS APPLICATION OF POLY ADP RIBOSE POLYMERASE INHIBITOR FUKANG (SHANGHAI) HEALTH TECHNOLOGY CO., LTD (CN) 2024-01-18 — — US disclosed
US-20050043336-A1 Quinazoline derivatives as antitumor agents ASTRAZENECA AB (SE) 2005-02-24 — — US disclosed
US-20040171614-A1 Novel gamma secretase inhibitors SCHERING-PLOUGH CORPORATION 2004-09-02 — — US disclosed
WO-2003007959-A1 QUINOXALINE DERIVATIVES WHICH HAVE PARP INHIBITORY ACTION FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2003-01-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240025887-A1 THIENYL AND CYCLOALKYL AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF NUAK1, NUAK2, PNKP PHGDH 1008/4885MGLL 3202/4885LMNA 1647/4885
US-20040171614-A1 Novel gamma secretase inhibitors BACE1, BACE2, APP PHGDH 3771/4885MGLL 1279/4885LMNA 1178/4885
US-20090318696-A1 Synthesis and use of MSE-framework type molecular sieves ETV6, TERF2, ASF1A PHGDH 4300/4885MGLL 3690/4885LMNA 3610/4885
US-20070282101-A1 Indazole compounds CYP3A43, CYP3A7, UGT1A1 PHGDH 573/4885MGLL 3633/4885LMNA 3544/4885
US-20050043336-A1 Quinazoline derivatives as antitumor agents ERBB2, ERBB3, ABL1 PHGDH 3003/4885MGLL 4718/4885LMNA 3367/4885
US-20240016775-A1 ANTI-CORONAVIRUS APPLICATION OF POLY ADP RIBOSE POLYMERASE INHIBITOR PARP3, PARP1, PARP4 PHGDH 1701/4885MGLL 3161/4885LMNA 370/4885
US-20120053345-A1 Indazole Compounds CYP3A43, CYP3A7, UGT1A1 PHGDH 573/4885MGLL 3633/4885LMNA 3544/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.