SCHEMBL5089917

SCHEMBL5089917

C=CCOc1c(Br)cc(C)cc1[Si](C)(C)C(C)(C)C

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.43
KMT2A Q03164 5/20 0.43
LMNA P02545 4/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
ALDH1A1 P00352 1/20 0.39
HTT P42858 2/20 0.36
GAA P10253 2/20 0.35
L3MBTL1 Q9Y468 3/20 0.34
KDM4E B2RXH2 1/20 0.34
PKM P14618 1/20 0.34
MAPT P10636 3/20 0.34
PTGS1 P23219 3/20 0.34
PTGS2 P35354 3/20 0.34
HPGD P15428 1/20 0.34
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5085915 0.85 KMT2A (0.44) MEN1KMT2ALMNASMN1; SMN2ALDH1A1
SCHEMBL5089753 0.80 MEN1 (0.40) MEN1KMT2ALMNASMN1; SMN2ALDH1A1
SCHEMBL6578128 0.80 LMNA (0.47) MEN1KMT2ALMNASMN1; SMN2ALDH1A1
SCHEMBL5084191 0.77 ACHE (0.39) MEN1KMT2ALMNAALDH1A1HTT
SCHEMBL29605909 0.77 SMN1; SMN2 (0.40) MEN1KMT2ALMNASMN1; SMN2ALDH1A1
SCHEMBL5086388 0.77 SMN1; SMN2 (0.40) MEN1KMT2ALMNASMN1; SMN2ALDH1A1
SCHEMBL5090126 0.76 MAPT (0.33) MAPT
SCHEMBL5086988 0.76 MAPT (0.47) MEN1KMT2ALMNASMN1; SMN2ALDH1A1
SCHEMBL5085828 0.75
SCHEMBL5090608 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1498178-B1 Transition metal complex and process for producing the same SUMITOMO CHEMICAL CO (JP) 2008-06-11 EP disclosed
EP-1498178-A2 Transition metal complex, process for producing the same, olefin polymerization catalyst containing the transition metal complex and process for producing olefin polymers Sumitomo Chemical Company, Limited (JP) 2005-01-19 EP disclosed
CN-1185236-C Transition metal compound, its producing process olefine polymerization catalyst containing the same transition metal compound and process for producing olefine polymer SUMITOMO CHEMICAL CO (JP) 2005-01-19 CN disclosed
EP-0842939-B1 OLEFIN POLYMERIZATION CATALYST CONTAINING A TRANSITION METAL COMPLEX AND PROCESS FOR PRODUCING OLEFIN POLYMERS SUMITOMO CHEMICAL CO (JP) 2004-10-06 EP disclosed
US-6329478-B1 SOLUBILITY IN SATURATED HYDROCARBON SOLVENTS SUMITMO CHEMICAL COMPANY, LIMITED 2001-12-11 US disclosed
CN-1310183-A Transition metal compound, its producing process olefine polymerization catalyst containing the same transition metal compound and process for producing olefine polymer SUMITOMO CHEMICAL CO (JP) 2001-08-29 CN disclosed
CN-1068884-C Transition metal complex, process for producing the same, olefin polymerization catalyst containing the transition metal complex, and process for producing olefin polymer SUMITOMO CHEM IND (JP) 2001-07-25 CN disclosed
CN-1193323-A Transition metal complex, process for producing the same, olefin polymerization catalyst containing the transition metal complex, and process for producing olefin polymer SUMITOMO CHEM IND (JP) 1998-09-16 CN disclosed
EP-0842939-A1 TRANSITION METAL COMPLEX, PROCESS FOR THE PREPARATION THEREOF, POLYMERIZATION CATALYST FOR OLEFINS CONTAINING THE COMPLEX, AND PROCESS FOR PRODUCING OLEFIN POLYMERS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-05-20 EP disclosed