Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.43 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.42 |
| ▸ | ACACB | O00763 | 8/20 | 0.42 |
| ▸ | NNMT | P40261 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GPR183 | P32249 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048946 | 0.84 | GRM5 (0.42) | GRM5ACACBKCNH2GPR183 | |
| SCHEMBL2285672 | 0.80 | GRM5 (0.42) | GRM5 | |
| SCHEMBL28811006 | 0.76 | GRM5 (0.47) | GRM5HAO1 | |
| SCHEMBL22324962 | 0.76 | QDPR (0.47) | KCNH2 | |
| SCHEMBL8675743 | 0.76 | GRM5 (0.49) | GRM5 | |
| SCHEMBL4536276 | 0.75 | GRM5 (0.40) | GRM5 | |
| SCHEMBL5102974 | 0.73 | HAO1 (0.40) | GRM5HAO1ACACBNNMT | |
| SCHEMBL20599946 | 0.73 | GRM5 (0.56) | GRM5 | |
| SCHEMBL2290995 | 0.71 | GRM5 (0.44) | GRM5KCNH2 | |
| SCHEMBL2892482 | 0.71 | GRM5 (0.43) | GRM5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004317-A1 | Compounds | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004317-A1 | Compounds | CYP1A2, CYP2D6, F12 | GRM5 3038/4885HAO1 3263/4885ACACB 2911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.