Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5097544 | 0.87 | HPGD (0.46) | LMNAHPGDHTTHDAC6HDAC3 | |
| SCHEMBL5085616 | 0.85 | HPGD (0.40) | HPGDHTTHDAC6HDAC3HDAC4 | |
| SCHEMBL4401368 | 0.72 | KDM4E (0.40) | HDAC6CA1CA2CA9 | |
| SCHEMBL4401363 | 0.72 | KDM4E (0.40) | HDAC6CA1CA2CA9 | |
| SCHEMBL5090684 | 0.72 | ALDH1A1 (0.39) | LMNAHPGDHTTHDAC6HDAC3 | |
| SCHEMBL5139867 | 0.71 | HDAC3 (0.50) | HPGDHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL5806467 | 0.68 | HDAC3 (0.62) | LMNAHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL5138320 | 0.65 | FAAH (0.34) | LMNAHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL5095946 | 0.65 | HTT (0.47) | HTT | |
| SCHEMBL5087320 | 0.64 | FAAH (0.41) | HDAC6HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968609-A2 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF HIGHLY LIPOPHILIC SULFHYDRYL COMPOUNDS | RND Pharmaceuticals, Inc. (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007073560-A2 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF HIGHLY LIPOPHILIC SULFHYDRYL COMPOUNDS | RND PHARMACEUTICALS, INC. (US) | 2007-06-28 | — | — | WO | disclosed |