Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.59 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5098943 | 0.89 | PTGDR2 (0.56) | PTGDR2PTGER1L3MBTL1TDP1USP2 | |
| SCHEMBL5099579 | 0.87 | PTGDR2 (0.64) | PTGDR2PTGER1L3MBTL1TDP1USP2 | |
| SCHEMBL5089021 | 0.86 | PTGDR2 (0.53) | PTGDR2USP2MAPT | |
| SCHEMBL5091200 | 0.85 | LMNA (0.57) | PTGDR2L3MBTL1TDP1USP2MAPT | |
| SCHEMBL5091264 | 0.85 | PTGDR2 (0.53) | PTGDR2L3MBTL1TDP1USP2MAPT | |
| SCHEMBL5088958 | 0.83 | PTGDR2 (0.50) | PTGDR2PTGER1USP2MAPT | |
| SCHEMBL5091226 | 0.81 | PTGDR2 (0.53) | PTGDR2USP2MAPT | |
| SCHEMBL5094242 | 0.81 | PTGDR2 (0.55) | PTGDR2PTGER1L3MBTL1TDP1USP2 | |
| SCHEMBL5098954 | 0.79 | PTGDR2 (0.55) | PTGDR2USP2MAPT | |
| SCHEMBL5099650 | 0.78 | PTGDR2 (0.47) | PTGDR2PTGER1L3MBTL1TDP1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7323570-B2 | Farnesyltransferase inhibitors | ABBOTT LABORATORIES (US) | 2008-01-29 | — | — | US | disclosed |
| US-7211595-B2 | Farnesyltransferase inhibitors | ABBOTT LABORATORIES (US) | 2007-05-01 | — | — | US | disclosed |
| US-20060264476-A1 | Farnesyltransferase Inhibitors | ABBVIE INC. | 2006-11-23 | — | — | US | disclosed |
| EP-1339695-B1 | FARNESYLTRANSFERASE INHIBITORS | ABBOTT LAB (US) | 2006-04-19 | — | — | EP | disclosed |
| US-20030087940-A1 | Farnesyltransferase inhibitors | ABBVIE INC. | 2003-05-08 | — | — | US | disclosed |
| US-20020115640-A1 | Such as 4-(((6-chloro-2-(3-chlorophenyl)-3-pyridinyl) methoxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile; anticancer agents | ABBOTT LABORATORIES | 2002-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020115640-A1 | Such as 4-(((6-chloro-2-(3-chlorophenyl)-3-pyridinyl) methoxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile; anticancer agents | FNTB, FNTA, ACAT2 | PTGDR2 4612/4885PTGER1 3281/4885PTGER2 4331/4885 |
| US-20060264476-A1 | Farnesyltransferase Inhibitors | FNTB, FNTA, FDPS | PTGDR2 3285/4885PTGER1 1535/4885PTGER2 2392/4885 |
| US-20030087940-A1 | Farnesyltransferase inhibitors | FNTB, FNTA, FDPS | PTGDR2 3106/4885PTGER1 697/4885PTGER2 2101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.