Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2585749 | 1.00 | ALDH1A1 (0.48) | ALDH1A1TSHRMEN1KMT2ATRPA1 | |
| SCHEMBL4522287 | 1.00 | ALDH1A1 (0.48) | ALDH1A1TSHRMEN1KMT2ATRPA1 | |
| SCHEMBL4087896 | 0.94 | TSHR (0.48) | ALDH1A1TSHRMEN1KMT2ATRPA1 | |
| SCHEMBL4511395 | 0.94 | TSHR (0.48) | ALDH1A1TSHRMEN1KMT2ATRPA1 | |
| SCHEMBL4511392 | 0.94 | TSHR (0.48) | ALDH1A1TSHRMEN1KMT2ATRPA1 | |
| SCHEMBL4511780 | 0.94 | TSHR (0.48) | ALDH1A1TSHRMEN1KMT2ATRPA1 | |
| SCHEMBL4512076 | 0.92 | MEN1 (0.50) | ALDH1A1TSHRMEN1KMT2ATRPA1 | |
| SCHEMBL2581567 | 0.84 | P2RX7 (0.41) | ALDH1A1TSHRMEN1KMT2AP2RX7 | |
| SCHEMBL2585743 | 0.83 | TRPA1 (0.38) | ALDH1A1TSHRMEN1KMT2ATRPA1 | |
| SCHEMBL4514655 | 0.81 | TSHR (0.42) | ALDH1A1TSHRMEN1KMT2ATRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953158-B1 | BICYCLIC CINNAMIDE COMPOUND | EISAI R&D MAN CO LTD (JP) | 2012-09-12 | — | — | EP | disclosed |
| EP-1953158-A1 | BICYCLIC CINNAMIDE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2008-08-06 | — | — | EP | disclosed |