Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | ACHE | P22303 | 12/20 | 0.60 |
| ▸ | BACE1 | P56817 | 11/20 | 0.60 |
| ▸ | BCHE | P06276 | 9/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.58 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956766 | 0.83 | MEN1 (0.57) | KMT2AMEN1POLBACHEBACE1 | |
| SCHEMBL2983341 | 0.83 | ACHE (0.78) | KMT2AMEN1POLBACHEBACE1 | |
| SCHEMBL2258425 | 0.83 | KMT2A (0.60) | KMT2AMEN1POLBACHEBACE1 | |
| SCHEMBL5093064 | 0.82 | KMT2A (0.63) | KMT2AMEN1POLBACHEBACE1 | |
| SCHEMBL3594567 | 0.82 | ACHE (0.71) | KMT2AMEN1POLBACHEBACE1 | |
| Hydrochloric Acid SCHEMBL11100747 | 0.81 | ACHE (0.70) | KMT2AMEN1POLBACHEBACE1 | |
| Hydrochloric Acid SCHEMBL15006724 | 0.81 | ACHE (0.70) | KMT2AMEN1POLBACHEBACE1 | |
| Hydrochloric Acid SCHEMBL15006925 | 0.81 | ACHE (0.70) | KMT2AMEN1POLBACHEBACE1 | |
| SCHEMBL16480389 | 0.77 | KMT2A (0.61) | KMT2AMEN1POLBACHEBACE1 | |
| SCHEMBL3599966 | 0.76 | MEN1 (0.69) | KMT2AMEN1POLBACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7407963-B2 | Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2008-08-05 | — | — | US | disclosed |
| US-20050267137-A1 | Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-12-01 | — | — | US | disclosed |
| EP-1228059-B1 | NOVEL CYCLOPROPANES AS CGRP ANTAGONISTS, MEDICAMENTS CONTAINING SAID COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM PHARMA (DE) | 2005-08-03 | — | — | EP | disclosed |
| US-20030139417-A1 | Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267137-A1 | Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof | CALCRL, CALCA, CALCR | KMT2A 4833/4885MEN1 864/4885POLB 3821/4885 |
| US-20030139417-A1 | Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof | CALCA, CALCRL, CALCB | KMT2A 4857/4885MEN1 667/4885POLB 3505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.