Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 10/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 9/20 | 0.54 |
| ▸ | CLK1 | P49759 | 8/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 8/20 | 0.52 |
| ▸ | CLK2 | P49760 | 7/20 | 0.52 |
| ▸ | CLK3 | P49761 | 3/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27543365 | 0.81 | PIM1 (0.48) | MAPK8PIK3CGGSK3BCAMKK2MAPK10 | |
| SCHEMBL5100716 | 0.80 | CAMKK2 (0.50) | MAPK8PIK3CGGSK3BCAMKK2MAPK10 | |
| SCHEMBL5089350 | 0.79 | CAMK2D (0.53) | MAPK8PIK3CGGSK3BCAMKK2MAPK10 | |
| SCHEMBL5094295 | 0.77 | PIK3CG (0.47) | MAPK8PIK3CGGSK3BCAMKK2MAPK10 | |
| SCHEMBL5091547 | 0.77 | CAMKK2 (0.53) | DYRK1ACLK4CLK1DYRK1BMAPK8 | |
| SCHEMBL5091983 | 0.76 | MAPK8 (0.61) | MAPK8PIK3CGGSK3BCAMKK2MAPK10 | |
| SCHEMBL5089243 | 0.74 | MAPK8 (0.56) | MAPK8PIK3CGGSK3BCAMKK2MAPK10 | |
| SCHEMBL5094681 | 0.73 | MAPK8 (0.54) | DYRK1ACLK4CLK1DYRK1BCLK2 | |
| SCHEMBL5095220 | 0.73 | MAPK8 (0.58) | MAPK8PIK3CGGSK3BCAMKK2MAPK10 | |
| SCHEMBL5099819 | 0.72 | HDAC1 (0.56) | DYRK1ACLK4CLK1DYRK1BCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7425557-B2 | Inhibitors of glycogen synthase kinase 3 | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-16 | — | — | US | disclosed |
| US-7045519-B2 | Inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION (US) | 2006-05-16 | — | — | US | disclosed |
| US-7037918-B2 | Inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION (US) | 2006-05-02 | — | — | US | disclosed |
| US-20060089369-A1 | Inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION (US) | 2006-04-27 | — | — | US | disclosed |
| US-20030130289-A1 | Inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION | 2003-07-10 | — | — | US | disclosed |
| US-6489344-B1 | FOR TREATMENT DIABETES IN A HUMAN OR ANIMAL SUBJECT | CHIRON CORPORATION | 2002-12-03 | — | — | US | disclosed |
| US-20020156087-A1 | Inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION | 2002-10-24 | — | — | US | disclosed |
| US-6417185-B1 | HETEROCYCLIC ENZYME INHIBITORS | CHIRON CORPORATION | 2002-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130289-A1 | Inhibitors of glycogen synthase kinase 3 | GSK3B, GSK3A, PYGB | DYRK1A 325/4885CLK4 1080/4885CLK1 787/4885 |
| US-20060089369-A1 | Inhibitors of glycogen synthase kinase 3 | GSK3B, GSK3A, PYGB | DYRK1A 319/4885CLK4 1015/4885CLK1 731/4885 |
| US-20020156087-A1 | Inhibitors of glycogen synthase kinase 3 | GSK3B, GSK3A, PYGB | DYRK1A 319/4885CLK4 1015/4885CLK1 731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.