Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | F7 | P08709 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 8/20 | 0.44 |
| ▸ | F10 | P00742 | 3/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5094020 | 0.89 | POLB (0.50) | CA1CA2POLBNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL5089093 | 0.88 | CA1 (0.49) | CA1CA2POLBNPC1RAB9A | |
| SCHEMBL5177698 | 0.83 | ALDH1A1 (0.52) | CA1CA2POLBF10PRSS1 | |
| SCHEMBL5564415 | 0.82 | CA1 (0.44) | CA1CA2POLBNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL5089718 | 0.82 | ALDH1A1 (0.51) | CA1CA2POLBPRSS1 | |
| SCHEMBL8266386 | 0.82 | F10 (0.45) | CA1CA2POLBNPC1RAB9A | |
| SCHEMBL5178069 | 0.82 | KLKB1 (0.51) | CA2KLKB1 | |
| Hydrochloric Acid SCHEMBL5089572 | 0.81 | CA1 (0.43) | CA1CA2POLBNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL5139096 | 0.81 | F10 (0.46) | CA1CA2POLBRAB9AF2 | |
| SCHEMBL8267082 | 0.81 | HDAC8 (0.53) | CA1CA2NPC1RAB9AF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008512364-A | — | — | 2008-04-24 | — | — | JP | claimed |
| EP-1791810-A1 | 4-AMINOMETHYL BENZAMIDINE DERIVATIVES AND THEIR USE AS FACTOR VIIA INHIBITORS | F. Hoffmann-Roche AG (CH) | 2007-06-06 | — | — | EP | claimed |
| WO-2006027135-A1 | 4-AMINOMETHYL BENZAMIDINE DERIVATIVES AND THEIR USE AS FACTOR VIIIA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-16 | — | — | WO | claimed |
| EP-1791810-A1 | 4-AMINOMETHYL BENZAMIDINE DERIVATIVES AND THEIR USE AS FACTOR VIIA INHIBITORS | F. Hoffmann-Roche AG (CH) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006027135-A1 | 4-AMINOMETHYL BENZAMIDINE DERIVATIVES AND THEIR USE AS FACTOR VIIIA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-16 | — | — | WO | disclosed |