Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27259214 | 0.87 | SIGMAR1 (0.56) | SIGMAR1ALDH1A1SMN1; SMN2KDM4EALOX15 | |
| SCHEMBL4578879 | 0.85 | SIGMAR1 (0.55) | SIGMAR1ALDH1A1SMN1; SMN2KDM4EALOX15 | |
| SCHEMBL8396113 | 0.85 | SIGMAR1 (0.55) | SIGMAR1ALDH1A1SMN1; SMN2KDM4EALOX15 | |
| SCHEMBL11952855 | 0.84 | SIGMAR1 (0.54) | SIGMAR1ALDH1A1SMN1; SMN2KDM4EALOX15 | |
| SCHEMBL4579797 | 0.82 | ALDH1A1 (0.77) | SIGMAR1ALDH1A1SMN1; SMN2KDM4ETDP1 | |
| SCHEMBL4578090 | 0.82 | ALDH1A1 (0.70) | SIGMAR1ALDH1A1SMN1; SMN2KDM4ETDP1 | |
| SCHEMBL8434592 | 0.81 | SIGMAR1 (0.54) | SIGMAR1ALDH1A1SMN1; SMN2KDM4EALOX15 | |
| SCHEMBL4578358 | 0.81 | ALDH1A1 (0.81) | SIGMAR1ALDH1A1SMN1; SMN2KDM4ETDP1 | |
| SCHEMBL17937116 | 0.81 | ALDH1A1 (0.71) | SIGMAR1ALDH1A1SMN1; SMN2KDM4EALOX15 | |
| SCHEMBL12906765 | 0.80 | ALDH1A1 (0.53) | SIGMAR1ALDH1A1SMN1; SMN2KDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951686-B1 | QUINAZOLINE DERIVATIVES AS A MULTIPLEX INHIBITOR AND METHOD FOR THE PREPARATION THEREOF | HANMI PHARM IND CO LTD (KR) | 2013-04-03 | — | — | EP | claimed |
| US-20080318950-A1 | Quinazoline Derivatives as a Multiplex Inhibitor and Method For the Preparation Thereof | HANMI PHARM. CO., LTD (KR) | 2008-12-25 | — | — | US | claimed |
| US-8846699-B2 | Quinazoline derivatives as a multiplex inhibitor and method for the preparation thereof | HANMI PHARM. CO., LTD. (KR) | 2014-09-30 | — | — | US | disclosed |
| EP-1951686-B1 | QUINAZOLINE DERIVATIVES AS A MULTIPLEX INHIBITOR AND METHOD FOR THE PREPARATION THEREOF | HANMI PHARM IND CO LTD (KR) | 2013-04-03 | — | — | EP | disclosed |
| CN-101304978-B | Quinazoline derivative as multi-component inhibitor, pharmaceutical composition and application | HANMI PHARM IND CO LTD | 2012-12-26 | — | — | CN | disclosed |
| US-20080318950-A1 | Quinazoline Derivatives as a Multiplex Inhibitor and Method For the Preparation Thereof | HANMI PHARM. CO., LTD (KR) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318950-A1 | Quinazoline Derivatives as a Multiplex Inhibitor and Method For the Preparation Thereof | ABL1, JAK1, BTK | SIGMAR1 3484/4885ALDH1A1 3502/4885SMN1; SMN2 3956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.