Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.90 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.66 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PRKCI | P41743 | 2/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL614900 | 0.95 | HTR2C (1.00) | HTR2CHRH4PIK3CAKDM4EMAPT | |
| SCHEMBL602499 | 0.85 | HTR2C (0.65) | HTR2CHRH4PIK3CAKDM4EPRKCI | |
| SCHEMBL2392391 | 0.78 | PIK3CA (0.73) | HTR2CHRH4PIK3CAPRKCILIMK1 | |
| SCHEMBL5235576 | 0.75 | PTK2 (0.60) | HTR2CHRH4KDM4EMAPTLMNA | |
| SCHEMBL9722339 | 0.73 | KDM4E (0.88) | HTR2CKDM4EMAPT | |
| SCHEMBL19805137 | 0.73 | HTR2C (0.62) | HTR2CHRH4PIK3CAKDM4EPRKCI | |
| SCHEMBL16922590 | 0.71 | HRH4 (0.59) | HTR2CHRH4PIK3CALIMK1CDK5 | |
| SCHEMBL605467 | 0.69 | DRD2 (0.64) | HTR2CKDM4EPRKCILMNAMAPK1 | |
| SCHEMBL29936658 | 0.68 | PTK2 (0.67) | HTR2CHRH4KDM4EMAPTLMNA | |
| Benzisothiazole-3-Yl-Piperazine SCHEMBL29432928 | 0.68 | KDM4E (0.97) | HTR2CKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269239-A1 | Pyrimidine Compounds as Histamine Modulators | ARGENTA DISCOVERY LTD. (GB) | 2008-10-30 | — | — | US | claimed |
| EP-1812113-A1 | PYRIMIDINE COMPOUNDS AS HISTAMINE MODULATORS | Argenta Discovery Limited (GB) | 2007-08-01 | — | — | EP | claimed |
| WO-2006050965-A1 | PYRIMIDINE COMPOUNDS AS HISTAMINE MODULATORS | ARGENTA DISCOVERY LTD (GB) | 2006-05-18 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269239-A1 | Pyrimidine Compounds as Histamine Modulators | HRH4, HRH3, HRH2 | HTR2C 138/4885HRH4 1/4885PIK3CA 732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.