Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319937 | 0.84 | SMN1; SMN2 (0.52) | POLBTSHRMAPK1ACHECA9 | |
| SCHEMBL2217165 | 0.82 | CYP3A4 (0.52) | POLBTSHRMAPK1ACHECA9 | |
| SCHEMBL7246613 | 0.82 | CA9 (0.49) | POLBTSHRMAPK1ACHECA9 | |
| SCHEMBL7319931 | 0.82 | CA9 (0.49) | POLBTSHRMAPK1ACHECA9 | |
| SCHEMBL4005582 | 0.82 | CA9 (0.68) | ACHECA9CA12CA1CA2 | |
| SCHEMBL2368094 | 0.82 | CA9 (0.49) | POLBTSHRMAPK1ACHECA9 | |
| SCHEMBL725276 | 0.80 | EGFR (0.55) | POLBTSHRMAPK1CA9CA12 | |
| SCHEMBL5982255 | 0.79 | POLB (0.57) | POLBTSHRMAPK1CA9CA12 | |
| SCHEMBL9490711 | 0.79 | POLB (0.57) | POLBTSHRMAPK1CA9CA12 | |
| SCHEMBL9112719 | 0.77 | CA9 (0.45) | POLBTSHRMAPK1ACHECA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7410998-B2 | Inhibitors of NADH:ubiquinone oxidoreductase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-08-12 | — | — | US | disclosed |
| US-20040034239-A1 | Inhibitors of nadh:ubiquinone oxidoreductase | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-02-19 | — | — | US | disclosed |
| WO-2002020008-A1 | INHIBITORS OF NADH:UBIQUINONE OXIDOREDUCTASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2002-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034239-A1 | Inhibitors of nadh:ubiquinone oxidoreductase | NQO1, NDUFV1, NDUFV2 | POLB 547/4885TSHR 4756/4885MAPK1 3138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.