Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 4/20 | 0.49 |
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2494498 | 0.86 | CA9 (0.40) | CA9CA1CA2CA12ACHE | |
| SCHEMBL10565520 | 0.82 | KDM4E (0.46) | MAPTMAPK1ALDH1A1KDM4EHTR1A | |
| SCHEMBL12626309 | 0.82 | MAPT (0.42) | CA9CA1CA2CA12MAPT | |
| SCHEMBL5095441 | 0.82 | POLB (0.59) | CA9CA1CA2CA12ACHE | |
| SCHEMBL31511125 | 0.81 | TSHR (0.44) | MAPTPOLBTSHRMAPK1TRPV4 | |
| SCHEMBL7319937 | 0.80 | SMN1; SMN2 (0.52) | CA9CA1CA2CA12ACHE | |
| SCHEMBL7319931 | 0.78 | CA9 (0.49) | CA9CA1CA2CA12ACHE | |
| SCHEMBL2217165 | 0.78 | CYP3A4 (0.52) | CA9CA1CA2CA12ACHE | |
| SCHEMBL5212407 | 0.78 | ALDH1A1 (0.38) | CA9CA1CA2CA12ACHE | |
| SCHEMBL14120915 | 0.78 | PTGS2 (0.44) | CA9CA1CA2MAPTTRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3212613-B1 | (Z)-3,4,5-TRIMETHOXYSTYRYLBENZENESULFONAMIDES AS POTENTIAL ANTICANCER AGENTS | COUNCIL SCIENT IND RES (IN) | 2020-12-16 | — | — | EP | disclosed |
| US-10246411-B2 | (Z)-3,4,5-trimethoxystyrylbenzenesulfonamides as potential anticancer agents | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2019-04-02 | — | — | US | disclosed |
| US-20170327462-A1 | (Z)-3,4,5-TRIMETHOXYSTYRYLBENZENESULFONAMIDES AS POTENTIAL ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-11-16 | — | — | US | disclosed |
| US-20170327462-A1 | (Z)-3,4,5-TRIMETHOXYSTYRYLBENZENESULFONAMIDES AS POTENTIAL ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-11-16 | — | — | US | disclosed |
| EP-2488177-B1 | FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC | PAIN THERAPEUTICS INC (US) | 2016-10-12 | — | — | EP | disclosed |
| US-20160251374-A1 | FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC | BURNS BARBIER LINDSAY (US) | 2016-09-01 | — | — | US | disclosed |
| US-9340558-B2 | Filamin a binding anti-inflammatory and analgesic | PAIN THERAPEUTICS INC. (US) | 2016-05-17 | — | — | US | disclosed |
| WO-2016067311-A1 | (Z)-3,4,5-TRIMETHOXYSTYRYLBENZENESULFONAMIDES AS POTENTIAL ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-05-06 | — | — | WO | disclosed |
| EP-2366687-B1 | Benzenesulfonamide derivatives and pharmaceutical composition thereof | PURZER PHARMACEUTICAL CO LTD (CN) | 2015-11-04 | — | — | EP | disclosed |
| EP-2918587-A2 | Filamin a binding anti-inflammatory and analgesic | Pain Therapeutics, Inc. (US) | 2015-09-16 | — | — | EP | disclosed |
| EP-0395446-B1 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | SANKYO CO (JP) | 1995-03-01 | — | — | EP | disclosed |
| US-5389630-A | Diamine compound and brain protecting agent containing the same | KOWA CO., LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| US-5369106-A | N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists | SANKYO COMPANY, LIMITED (JP) | 1994-11-29 | — | — | US | disclosed |
| EP-0541798-A1 | NEW DIAMINE COMPOUND AND BRAIN PROTECTING AGENT CONTAINING THE SAME | Kowa Company Ltd. (JP) | 1993-05-19 | — | — | EP | disclosed |
| US-5192766-A | Platelet activating factor antagonist | SANKYO COMPANY, LIMITED (JP) | 1993-03-09 | — | — | US | disclosed |
| EP-0395446-A2 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | Sankyo Company Limited (JP) | 1990-10-31 | — | — | EP | disclosed |
| US-4257952-A | PSYCHOTROPIC DRUGS, ANALGESICS, ANTIHISTAMINES | STERLING DRUG INC. (US) | 1981-03-24 | — | — | US | disclosed |
| US-4172834-A | ANALGESICS, ANTIHISTAMINES AND PSYCHOTROPIC AGENTS | STERLING DRUG INC. (US) | 1979-10-30 | — | — | US | disclosed |
| US-4062864-A | ANALGESIC, PSYCHOTROPIC, ANTIHISTAMINE | STERLING DRUG INC. (US) | 1977-12-13 | — | — | US | disclosed |
| US-3959309-A | ANALGESICS, PSYCHOTROPIC, ANTIHISTAMINE | STERLING DRUG INC. (US) | 1976-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160251374-A1 | FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC | FLNA, FLNB, OPRK1 | CA9 4261/4885CA1 4454/4885CA2 3299/4885 |
| US-10246411-B2 | (Z)-3,4,5-trimethoxystyrylbenzenesulfonamides as potential anticancer agents | BCL3, CASP3, HCCS | CA9 98/4885CA1 1312/4885CA2 1347/4885 |
| US-20170327462-A1 | (Z)-3,4,5-TRIMETHOXYSTYRYLBENZENESULFONAMIDES AS POTENTIAL ANTICANCER AGENTS | BCL3, CASP3, HCCS | CA9 202/4885CA1 2478/4885CA2 2281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.