SCHEMBL5095572

SCHEMBL5095572

CCC(=O)c1nc2cc(Cl)ccc2o1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.51
KMT2A Q03164 4/20 0.51
CASP3 P42574 4/20 0.50
SENP7 Q9BQF6 3/20 0.50
XDH P47989 1/20 0.50
SENP8 Q96LD8 1/20 0.50
SENP6 Q9GZR1 1/20 0.50
TP53 P04637 1/20 0.49
MAPT P10636 4/20 0.49
LMNA P02545 2/20 0.49
MAPK1 P28482 2/20 0.49
CYP1A2 P05177 1/20 0.49
THRB P10828 1/20 0.49
ALOX15 P16050 1/20 0.49
TDP1 Q9NUW8 2/20 0.47
NPC1 O15118 1/20 0.47
POLB P06746 1/20 0.47
RAB9A P51151 1/20 0.47
KDM4E B2RXH2 2/20 0.46
HPGD P15428 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27654631 0.84 MAPT (0.58) MEN1KMT2ACASP3SENP7XDH
SCHEMBL10829015 0.81 MAOB (0.52) MEN1KMT2ACASP3SENP7XDH
SCHEMBL11233556 0.81 MAPT (0.54) MEN1KMT2ACASP3SENP7XDH
SCHEMBL29825622 0.81 MEN1 (0.56) MEN1KMT2ACASP3SENP7XDH
SCHEMBL3640007 0.81 MEN1 (0.56) MEN1KMT2ACASP3SENP7XDH
SCHEMBL2701430 0.80 MAPT (0.57) MEN1KMT2ACASP3SENP7XDH
SCHEMBL10829024 0.79 MAPT (0.56) MEN1KMT2ACASP3SENP7XDH
SCHEMBL10829146 0.78 XDH (0.52) MEN1KMT2ACASP3SENP7XDH
SCHEMBL11937009 0.78 FAAH (0.59) MEN1KMT2AXDHTP53MAPT
Eclazolast SCHEMBL636302 0.76 MEN1 (0.46) MEN1KMT2ACASP3SENP7XDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7402548-B2 Benzoxazole compounds, process for producing the same and herbicides KYOYU AGRI CO., LTD. (JP) 2008-07-22 US disclosed
US-7402548-B2 Benzoxazole compounds, process for producing the same and herbicides KYOYU AGRI CO., LTD. (JP) 2008-07-22 US disclosed
US-7402548-B2 Benzoxazole compounds, process for producing the same and herbicides KYOYU AGRI CO., LTD. (JP) 2008-07-22 US disclosed
EP-1637525-B1 Benzoxazole compound, process for producing the same, and herbicides KYOYU AGRI CO LTD (JP) 2007-12-19 EP disclosed
EP-1637525-B1 Benzoxazole compound, process for producing the same, and herbicides KYOYU AGRI CO LTD (JP) 2007-12-19 EP disclosed
EP-1681287-A1 Benzoxazole compounds, process for producing the same, and herbicides Ube Industries, Ltd. (JP) 2006-07-19 EP disclosed
EP-1681286-A1 Benzoxazole compounds, process for producing the same, and herbicides Ube Industries, Ltd. (JP) 2006-07-19 EP disclosed
EP-1637525-A1 Benzoxazole compound, process for producing the same, and herbicides Ube Industries, Ltd. (JP) 2006-03-22 EP disclosed
US-20050233909-A1 Benzoxazole compounds, process for producing the same and herbicides UBE INDUSTRIES, LTD. (JP) 2005-10-20 US disclosed
US-6844295-B2 Benzoxazole compound, process for producing the same, and herbicide UBE INDUSTRIES, LTD. (JP) 2005-01-18 US disclosed
US-20040014977-A1 Benzoxazole compound, process for producing the same, and herbicide KYOYU AGRI CO., LTD. (JP) 2004-01-22 US disclosed
EP-1302466-A1 BENZOXAZOLE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND HERBICIDE Ube Industries, Ltd. (JP) 2003-04-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050233909-A1 Benzoxazole compounds, process for producing the same and herbicides CBR3, CBR1, CYP4X1 MEN1 3741/4885KMT2A 1498/4885CASP3 1750/4885
US-20040014977-A1 Benzoxazole compound, process for producing the same, and herbicide CBR1, CBR3, CYP4X1 MEN1 4366/4885KMT2A 1182/4885CASP3 2147/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.