Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGXT | P21549 | 3/20 | 0.65 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.63 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.49 |
| ▸ | KLK1 | P06870 | 1/20 | 0.49 |
| ▸ | CHKA | P35790 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.48 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.48 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL113799 | 1.00 | AGXT (0.65) | AGXTPRMT6KLKB1KLK1CHKA | |
| SCHEMBL109316 | 0.98 | AGXT (0.67) | AGXTPRMT6KLKB1KLK1CHKA | |
| SCHEMBL27662780 | 0.90 | AGXT (0.56) | AGXTPRMT6L3MBTL1L3MBTL3MBTD1 | |
| SCHEMBL2462500 | 0.84 | AGXT (0.62) | AGXTPRMT6CHKANCF1 | |
| SCHEMBL27585372 | 0.84 | AGXT (0.50) | AGXTPRMT6KLKB1KLK1L3MBTL1 | |
| SCHEMBL109344 | 0.82 | AGXT (0.69) | AGXTPRMT6CHKAKMT2AALDH1A1 | |
| SCHEMBL108136 | 0.82 | AGXT (0.69) | AGXTPRMT6KLKB1KLK1KMT2A | |
| SCHEMBL13157040 | 0.82 | AGXT (0.49) | AGXTPRMT6L3MBTL1L3MBTL3MBTD1 | |
| SCHEMBL27475990 | 0.82 | HTR7 (0.60) | AGXTALDH1A1MAPTHTT | |
| SCHEMBL27468903 | 0.82 | AGXT (0.49) | AGXTPRMT6LMNANCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318929-A1 | Pyrimidine Derivatives Useful as Inhibitors of Pkc-Theta | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318929-A1 | Pyrimidine Derivatives Useful as Inhibitors of Pkc-Theta | PRKCQ, PRKCZ, PRKAR2B | AGXT 3446/4885PRMT6 167/4885KLKB1 2242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.