Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 10/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 6/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5102172 | 0.81 | IRAK4 (0.49) | IRAK4CSNK2A1GSK3BHIPK2PIM1 | |
| SCHEMBL5102689 | 0.80 | IRAK4 (0.44) | IRAK4CCNT1CDK1CCNB1CDK9 | |
| SCHEMBL3823223 | 0.76 | CDK1 (0.53) | IRAK4CCNT1CDK1CCNB1CDK9 | |
| SCHEMBL3819868 | 0.75 | MAPK8 (0.66) | IRAK4CSNK2A1GSK3BHIPK2CDK2 | |
| SCHEMBL3817344 | 0.75 | MAPK8 (0.66) | IRAK4CSNK2A1GSK3BHIPK2CDK2 | |
| SCHEMBL5090337 | 0.73 | CYP11B1 (0.40) | IRAK4CCNT1CDK1CCNB1CDK9 | |
| SCHEMBL30459760 | 0.70 | CYP11B1 (0.43) | CCNT1CDK1CCNB1CDK9CDK7 | |
| SCHEMBL17683145 | 0.70 | CYP11B1 (0.43) | CCNT1CDK1CCNB1CDK9CDK7 | |
| SCHEMBL30006626 | 0.70 | MAPT (0.53) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL17683288 | 0.69 | NR3C1 (0.42) | CCNT1CDK1CCNB1CDK9CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399462-B2 | 4-[4-(4-benzyloxy-indol-1-yl)-pyrimidin-2-ylamino]-cyclohexanol; autoimmune, inflammatory, metabolic, neurological diseases as well as cancer and pain | ROCHE PALO ALTO LLC (US) | 2013-03-19 | — | — | US | disclosed |
| CN-101547917-A | Substituted pyrimidines and their use as JNK modulators | HOFFMANN LAROCHE (CH) | 2009-09-30 | — | — | CN | disclosed |
| US-20080146565-A1 | JNK modulators | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146565-A1 | JNK modulators | MAPKAPK2, MAPKAPK3, MAP3K10 | IRAK4 447/4885CSNK2A1 159/4885GSK3B 263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.