Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 3/20 | 0.40 |
| ▸ | DHODH | Q02127 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4649127 | 0.95 | ALOX15 (0.42) | ALOX15ALDH1A1PDE10AIDO1DHODH | |
| SCHEMBL5703854 | 0.92 | KDM4E (0.39) | ALOX15ALDH1A1PDE10AIDO1DHODH | |
| SCHEMBL5093369 | 0.88 | PLA2G2A (0.45) | PDE10AIDO1DHODHKDM4EHSD17B10 | |
| SCHEMBL5097666 | 0.86 | PPARA (0.42) | ALOX15ALDH1A1DHODHNR1H4 | |
| SCHEMBL5088569 | 0.85 | DHODH (0.45) | ALOX15ALDH1A1PDE10AIDO1DHODH | |
| SCHEMBL4620763 | 0.84 | PDE10A (0.52) | ALOX15ALDH1A1PDE10AIDO1DHODH | |
| SCHEMBL14255061 | 0.84 | KDM4E (0.38) | ALDH1A1PDE10AIDO1DHODHKDM4E | |
| SCHEMBL5090505 | 0.84 | PLA2G2A (0.48) | ALOX15ALDH1A1PDE10ADHODH | |
| SCHEMBL5098762 | 0.84 | KDM4E (0.43) | ALOX15ALDH1A1DHODHKDM4E | |
| SCHEMBL5088654 | 0.83 | CYSLTR1 (0.45) | DHODHNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |