Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 5/20 | 0.43 |
| ▸ | PPARD | Q03181 | 4/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5097666 | 0.95 | PPARA (0.42) | PPARAPPARDPPARGKCNH2HRH3 | |
| SCHEMBL5088654 | 0.92 | CYSLTR1 (0.45) | PPARAPPARDPPARGKCNH2HRH3 | |
| SCHEMBL5090593 | 0.89 | PLA2G2A (0.46) | KDM4ESMN1; SMN2PPARAPPARDPPARG | |
| SCHEMBL5088616 | 0.88 | MEN1 (0.44) | KDM4ESMN1; SMN2KCNH2HRH3DHODH | |
| SCHEMBL5088569 | 0.86 | DHODH (0.45) | KDM4EDHODHALDH1A1ALOX15 | |
| SCHEMBL5093263 | 0.86 | SCN9A (0.43) | KCNH2SCN9AALDH1A1 | |
| SCHEMBL4649127 | 0.86 | ALOX15 (0.42) | KDM4EDHODHALDH1A1ALOX15 | |
| SCHEMBL5088530 | 0.84 | DHODH (0.42) | PPARGDHODHALDH1A1ALOX15 | |
| SCHEMBL5097669 | 0.84 | PPARG (0.53) | PPARAPPARDPPARGLMNA | |
| SCHEMBL5097600 | 0.84 | ALOX15 (0.42) | KDM4EDHODHALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |