Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14288496 | 0.83 | SIGMAR1 (0.44) | SIGMAR1HTR2AHRH1SLC6A2SLC6A4 | |
| SCHEMBL9514760 | 0.81 | CARM1 (0.47) | CHRM2HTR2AHRH1CARM1PRMT6 | |
| SCHEMBL9574797 | 0.80 | SIGMAR1 (0.59) | CHRM2SIGMAR1HTR2AHRH1CARM1 | |
| SCHEMBL9574675 | 0.75 | SLC6A2 (0.68) | CHRM2SIGMAR1HTR2AHRH1SLC6A2 | |
| SCHEMBL13060870 | 0.75 | HTR2A (0.57) | CHRM2HTR2AHRH1SLC6A2SLC6A4 | |
| SCHEMBL9502040 | 0.74 | KCNH2 (0.46) | SIGMAR1HTR2AHRH1 | |
| SCHEMBL5099621 | 0.74 | GRIN1 (0.50) | CHRM2SIGMAR1HTR2AHRH1SLC6A2 | |
| SCHEMBL9155641 | 0.73 | SIGMAR1 (0.73) | CHRM2SIGMAR1CARM1PRMT6PRMT8 | |
| SCHEMBL27611422 | 0.73 | KCNH2 (0.49) | SIGMAR1HTR2AHRH1 | |
| SCHEMBL10513477 | 0.71 | HTR2A (0.47) | CHRM2SIGMAR1HTR2AHRH1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320993-B1 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents | ASTELLAS DEUTSCHLAND GMBH (DE) | 2008-01-22 | — | — | US | disclosed |
| EP-1042291-B1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE CO CHEM PHARM FAB (DE) | 2005-07-13 | — | — | EP | disclosed |
| EP-1042291-A1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | Klinge Pharma GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999031064-A1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE PHARMA GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |