Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.73 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.52 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.52 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828390 | 0.94 | SIGMAR1 (0.70) | SIGMAR1MAOAAOC3TAAR1SLC6A2 | |
| SCHEMBL16994453 | 0.87 | SIGMAR1 (0.73) | SIGMAR1MAOAAOC3SLC6A2SLC6A4 | |
| SCHEMBL7972498 | 0.87 | SIGMAR1 (0.72) | SIGMAR1MAOAAOC3SLC6A2SLC6A4 | |
| SCHEMBL11134428 | 0.86 | SIGMAR1 (0.96) | SIGMAR1AOC3TAAR1SLC6A2SLC6A4 | |
| SCHEMBL8210535 | 0.86 | CARM1 (0.68) | SIGMAR1AOC3TAAR1SLC6A2SLC6A4 | |
| SCHEMBL7371550 | 0.85 | SIGMAR1 (1.00) | SIGMAR1TAAR1 | |
| SCHEMBL8630352 | 0.85 | SIGMAR1 (0.62) | SIGMAR1AOC3SLC6A2SLC6A4SLC6A3 | |
| Demelverine SCHEMBL1516521 | 0.84 | SIGMAR1 (0.76) | SIGMAR1AOC3TAAR1SLC6A2SLC6A4 | |
| SCHEMBL9162073 | 0.84 | KCNH2 (0.54) | SIGMAR1CHRM2TAAR1 | |
| SCHEMBL14432680 | 0.83 | SIGMAR1 (0.70) | SIGMAR1AOC3TAAR1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430059-A | Treating heart disease | EISAI CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| EP-0399358-B1 | Butenoic acid derivatives | EISAI CO LTD (JP) | 1995-03-08 | — | — | EP | disclosed |
| EP-0633248-A1 | Butenoic acid derivatives | Eisai Co., Ltd. (JP) | 1995-01-11 | — | — | EP | disclosed |
| EP-0589491-A1 | Butenoic acid derivatives | Eisai Co., Ltd. (JP) | 1994-03-30 | — | — | EP | disclosed |
| US-5292770-A | Butenoic acid derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| US-5166188-A | Cardiovascular disorders, antiischemic agents | EISAI CO., LTD. (JP) | 1992-11-24 | — | — | US | disclosed |
| EP-0399358-A2 | Butenoic acid derivatives | Eisai Co., Ltd. (JP) | 1990-11-28 | — | — | EP | disclosed |