⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44722 | 0.83 | RAB9A (0.36) | — | |
| SCHEMBL660124 | 0.74 | FAAH (0.31) | — | |
| Hydrogen Sulfide SCHEMBL28323707 | 0.73 | FAAH (0.35) | — | |
| SCHEMBL1829946 | 0.73 | — | — | |
| SCHEMBL22095572 | 0.72 | POLB (0.36) | — | |
| SCHEMBL29183560 | 0.71 | — | — | |
| SCHEMBL22239356 | 0.70 | CYP1A2 (0.35) | — | |
| SCHEMBL4456754 | 0.70 | — | — | |
| SCHEMBL17152619 | 0.68 | ALDH1A1 (0.43) | — | |
| SCHEMBL6624601 | 0.67 | FAAH (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006013205-A1 | NEUROKININ-1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CONDITIONS RESPONSIVE TO TESTOSTERONE ELEVATION | SOLVAY PHARMACEUTICALS B.V. (NL) | 2006-02-09 | — | — | WO | claimed |
| US-20060030556-A1 | Neurokinin-1 receptor antagonists for the treatment of conditions responsive to testosterone elevation, including testosterone deficiency | SOLVAY PHARMACEUTICALS B.V. | 2006-02-09 | — | — | US | claimed |
| US-7320993-B1 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents | ASTELLAS DEUTSCHLAND GMBH (DE) | 2008-01-22 | — | — | US | disclosed |
| WO-2006013205-A1 | NEUROKININ-1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CONDITIONS RESPONSIVE TO TESTOSTERONE ELEVATION | SOLVAY PHARMACEUTICALS B.V. (NL) | 2006-02-09 | — | — | WO | disclosed |
| US-20060030556-A1 | Neurokinin-1 receptor antagonists for the treatment of conditions responsive to testosterone elevation, including testosterone deficiency | SOLVAY PHARMACEUTICALS B.V. | 2006-02-09 | — | — | US | disclosed |
| EP-1042291-B1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE CO CHEM PHARM FAB (DE) | 2005-07-13 | — | — | EP | disclosed |
| EP-1001309-B1 | Silver halide photographic light sensitive material and image forming method using thereof | KONISHIROKU PHOTO IND (JP) | 2005-01-19 | — | — | EP | disclosed |
| EP-1042291-A1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | Klinge Pharma GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999031064-A1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE PHARMA GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |