Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | COMT | P21964 | 4/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | GRK2 | P25098 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14311768 | 0.84 | CYP11B1 (0.57) | CYP11B1CYP11B2COMTMAPTHPGD | |
| SCHEMBL5096941 | 0.82 | SMN1; SMN2 (0.50) | CYP11B1CYP11B2COMTHTR1DMAPT | |
| SCHEMBL5097039 | 0.82 | CYP11B1 (0.38) | CYP11B1CYP11B2COMTHTR1DHTR1B | |
| SCHEMBL1602901 | 0.81 | MAPT (0.54) | CYP11B1CYP11B2COMTMAPTGSK3B | |
| SCHEMBL5096712 | 0.81 | CYP11B1 (0.59) | CYP11B1CYP11B2COMTLMNAGSK3B | |
| SCHEMBL5096786 | 0.81 | COMT (0.58) | CYP11B1CYP11B2COMTMAPTLMNA | |
| SCHEMBL5153636 | 0.79 | LMNA (0.48) | CYP11B1CYP11B2COMTLMNAMEN1 | |
| SCHEMBL5100672 | 0.78 | ALPL (0.49) | CYP11B1CYP11B2COMTMAPTLMNA | |
| SCHEMBL5103933 | 0.78 | CYP11B1 (0.47) | CYP11B1CYP11B2COMTLMNACYP2D6 | |
| SCHEMBL5104024 | 0.78 | HRH3 (0.48) | CYP11B1CYP11B2COMTLMNAGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008004100-A2 | THERAPEUTIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2008-01-10 | — | — | WO | disclosed |