Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 14/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.48 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5768425 | 0.85 | HTR6 (0.74) | HTR6MTNR1A | |
| SCHEMBL6944998 | 0.78 | AKR1C3 (0.55) | HTR6AKR1C3AKR1C2AKR1C4PTGS1 | |
| SCHEMBL6821035 | 0.77 | HTR6 (0.52) | HTR6MTNR1A | |
| SCHEMBL5092828 | 0.76 | HTR6 (0.42) | HTR6ALDH1A1 | |
| SCHEMBL5092915 | 0.73 | ALDH1A1 (0.41) | HTR6ALDH1A1HPGDNPSR1 | |
| SCHEMBL5654827 | 0.72 | HTR6 (0.54) | HTR6AKR1C3AKR1C2AKR1C4PTGS1 | |
| SCHEMBL18133072 | 0.72 | AKR1C3 (0.81) | HTR6AKR1C3AKR1C2AKR1C4PTGS1 | |
| SCHEMBL5767433 | 0.71 | HTR6 (0.58) | HTR6MTNR1A | |
| SCHEMBL3029516 | 0.70 | HTR6 (0.76) | HTR6AKR1C3AKR1C2AKR1C4PTGS1 | |
| SCHEMBL5094696 | 0.70 | HTR6 (0.48) | HTR6ALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7317035-B2 | Tetracyclic arylcarbonyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them | SUVEN LIFE SCIENCES LIMITED (IN) | 2008-01-08 | — | — | US | disclosed |